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Printable Handouts
Navigable Slide Index
- Introduction
- Contents
- Self-introduction
- Research interests
- Background
- Cancer treatment modalities
- Peptide-based strategies for cancer diagnosis and therapy
- Era of peptide drugs development
- Concept of Antibody Drug Conjugates (ADCs)
- Concept of Peptide Drug Conjugate (PDCs)
- Cellular internalization mechanism
- Chemotherapeutics as cytotoxic payloads
- Linker chemistry
- Receptor-targeting peptides
- Conjugation with fluorescent dye (non-cleavable linkers)
- Evaluation of the conjugated peptides
- Biological evaluation after treatment with peptides
- Optical animal imaging of fluorescent peptide analogues
- Conjugation with radionuclides (amide linkage)
- One-pot synthesis reaction of cyclic 99mTc-DTPA and peptides analogs
- Percent radiochemical purity of 99mTc labeled DTPA-peptide analogs
- Internalization and cytotoxic assays
- Ex vivo distribution study
- SPECT diagnostic study
Topics Covered
- Peptide based strategies for cancer treatment
- RGD based peptides
- Antibody Drug Conjugate (ADC)
- Peptide Drug Conjugate (PDC)
- Linker chemistry
- Receptor-targeting peptides
- Conjugation with dyes/radionuclides
- Cleavable or non-cleavable linkers
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Rizvi, S.F.A. (2025, June 30). Peptide-drug conjugates as therapeutic modality in drug development 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 1, 2025, from https://doi.org/10.69645/QQQE1984.Export Citation (RIS)
Publication History
- Published on June 30, 2025
Financial Disclosures
- There are no commercial/ financial matters to disclose.
Peptide-drug conjugates as therapeutic modality in drug development 1
Published on June 30, 2025
30 min
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Dr. Syed
Faheem Askari Rizvi.
I'm from the Center
for Molecular Imaging
School of Public Health,
Xiamen University in China.
Today, the topic of
my discussion is
Peptide-Drug Conjugates as
Therapeutic Modality
in Drug Development.
0:20
So the content of our talk
is a little bit of self-introduction,
research interests,
then I will give a
brief information
about the background
of my topic,
about cancer, about
peptide drugs,
and about peptide-drug
conjugates.
Next, we will discuss about
receptor-targeting peptides,
which are currently
undergoing clinical trials,
as well as some that
are FDA approved.
Next, we will discuss
about conjugation with
fluorescence dyes,
and conjugation
with radionuclides,
which also followed by
the peptide-drug
conjugates designed
on the basis of
pH-dependent linkers.
Finally, I will summarize
the conclusion of
this whole talk.
1:07
So this is a brief
introduction about me,
my background, and
my future career.
1:17
My research interests are
dependent on the drug
delivery and pharmacokinetics
with broad research focus
including but not limited to
various medications used in
the treatment of cancer,
Alzheimer's disease, and
on understanding the role
of biopharmaceuticals
as well as pharmacokinetics
in elucidating
the underlying importance
in optimizing drug therapy.
I have been an author of
more than 40 international
publications,
and I have been working as
an invited reviewer
for various journals.
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