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Pharmacokinetics, -dynamics and dosing considerations in children

Published on July 31, 2024   38 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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0:00
Welcome to this lecture on pharmacokinetics, pharmacodynamics, and dosing considerations in children. My name is Karel Allegaert. I'm affiliated to two university hospitals, the Erasmus Medical Center in Rotterdam, as well as KU Leuven in Belgium.
0:19
As you can see on the second slide, our intention is actually to reflect with you on pharmacokinetics, pharmacodynamics, and related to that, the safety of drugs in children, be it newborns, infants, or children, or even adolescents. As you can notice on this slide, this is fundamentally something different, if you compare clinical pharmacology in children compared to other populations, as a dose will result in a concentration, and a concentration will result in an effect or side effect. That's the simple PK, pharmacokinetics, as well as the pharmacodynamics. However, dosing will be mainly determined by maturational pharmacokinetics, while effects may also be driven by maturational pharmacodynamics.
1:09
This is not new, as you can see on the next slide, because we already realized, for more than 100 years, that children, or pediatrics, does not simply deal with small men and women, or miniature men and women. But they have their own independent range and horizon. In essence, a child is not just a small adult, and nor is a newborn just a small child.
1:34
To further reiterate on that, actually, a pregnant woman is neither a woman with just a big belly. All these special populations do have their specific characteristics that should be considered if you try to develop an appropriate pharmacotherapy, attaining the effects aimed for, as well as avoiding the side effects that should be avoided. If you look at the next slide,

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