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Microbiome therapies to treat gastrointestinal diseases

Published on March 30, 2023   35 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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0:00
Hello, my name is Dr. Patricia Bloom. I am an Assistant Professor at the University of Michigan. Today I'll be talking with you about Microbiome therapies to treat gastrointestinal diseases.
0:16
The key points I want to address today are that the microbiome is altered in many gastrointestinal diseases and microbiome therapies may restore healthy microbiome function there for treating some of those gastrointestinal diseases. There are many considerations in the development and testing of microbiome therapies, which we'll review today. The future of this field points to personalized microbiome therapies tailored to the individual, disease and microbiome state.
0:56
The microbiome here is defined as the indigenous microbial communities and the host environment they inhabit. The microbiome is able to influence many different organ systems in the body. As such, it is key to health as well as disease. The microbiome does many things, for example, produces enzymes. It is central to many different metabolic functions including carbohydrate, protein and lipid metabolism. The microbiome can prevent pathogen colonization, influences barrier function, manufacturers small molecules with systemic effects, and can have a central role in modulating the immune system. Because of these myriad effects of the microbiome, it is key to health and disease.
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Microbiome therapies to treat gastrointestinal diseases

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