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1. Introduction
2. Cancer-centric view
3. Issues with the cancer-centric view
4. THE CANCER IS SURROUNDED BY THE PATIENT
5. The cancer patient
6. Tumor Organismal Environment (TOE)
7. Overview of the Tumor Microenvironment (TME)
8. Plants and their immediate environment
9. Differential effects of ECM proteins on actin and focal adhesions
10. ECM proteins impact lung metastasis formation
11. The in vivo environment accelerates tumorigenesis
12. The Tumor Microenvironment (TME)
13. Principles of intra-TME interactions
14. Heraclitus
15. Bidirectional crosstalk
16. Principles of intra-TME interactions: Tumor progression
17. Tumor progression and regression
18. Tumor dormancy
19. Principles of intra-TME interactions: Pro- or anti-malignancy functions
20. Principles of intra-TME interactions: Hijacking physiological elements
21. Tumor cells hijack physiological elements
22. Principles of intra-TME interactions: Different tumor microenvironments
23. Metastasis kills
24. Site-specific metastasis
25. Early observations on site-specific metastasis
26. Stephen Paget
27. The TME shapes the phenotype of the tumor
28. The pre-metastatic niche
29. Formation of the pre-metastatic niche
30. Tumor-derived extracellular vesicles (EVs) and the pre-metastatic organ
31. The metastatic cascade (1)
32. Regulation of the metastatic cascade
33. Epithelial to Mesenchymal Transition (EMT)
34. The TME regulates the EMT
35. The metastatic cascade (2)
36. Intravasation
37. Circulating cancer cells interact with platelets
38. The role of platelets
39. Extravasation
40. Extravasation steps of cancer cells
41. Selectins and tumor cell rolling
42. The functional role of integrins in extravasation
43. Integrins involved in the firm adhesion of tumor cells to the endothelium
44. Chemokine receptor-mediated migration
45. Targeted migration of chemokine receptor-expressing cancer cells
46. The fate of tumor cells at metastatic organ sites
47. Metastatic-promoting and metastatic-restraining factors
48. Metastasis-restraining signals
49. The short peptide of human HBB (Metox) inhibits tumor growth
50. Metox inhibits neuroblastoma metastasis
51. Interactions between tumors and their microenvironment
52. Targeting tumor-TME interactions
53. 2018 Nobel Prize laureates James Allison & Tasuku Honjo
54. Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells
55. A history of exploring cancer in context
56. A rephrased statement of Stephen Paget (IPW)
57. Witz Team 2020-2021
58. My sincere thanks

Topics Covered

• Tumor Organismal Environment (TOE) and Tumor Microenvironment (TME)
• Principles of intra-TME interactions
• Tumor progression and regression
• Site-specific metastasis
• The pre-metastatic niche
• The metastatic cascade
• Epithelial to Mesenchymal Transition (EMT)
• Targeting tumor-TME interactions
• Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells

Links

Series:

• Periodic Reports: Advances in Clinical Interventions and Research Platforms

Categories:

• Cancer
• Clinical Practice

Therapeutic Areas:

• Oncology

Talk Citation

Witz, I.P. (2021, March 31). How tumor-microenvironment interactions drive or inhibit metastasis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/TCZM2907.
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Publication History

• Published on March 31, 2021

Financial Disclosures

• Prof. Isaac P. Witz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.