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RNA therapeutics: clinical applications and methods of delivery

Published on November 30, 2022   37 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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0:00
Hello, I'm Professor John Cooke. I'm the founding Director of the Center for RNA Therapeutics here at Houston Methodist Research Institute in the Texas Medical Center. Today's Henry Stewart Talk is going to be about "RNA Therapeutics, Clinical Applications, and Methods of Delivery".
0:22
Before I begin, let me disclose my conflicts. I am an inventor on RNA technologies assigned to Stanford University and to Houston Methodist Hospital. I'm the founder of ChromeX Bio which is developing mRNA telomerase therapies. I'm a member of the Scientific Advisory Board of Humann, Cordex Bio,and JanOne. And I'm the principal investigator on sponsored research agreements with Avita and VGXI.
0:50
We're going to be talking today about messenger RNA, but just a slide to remind us of the diversity of RNA species. In addition to messenger RNA, there's transfer RNA, ribosomal RNA, microRNA, long non-coding RNA, et cetera. That diversity of RNA also represents some great opportunities for therapeutic development.
1:13
Indeed, there is a diversity of RNA drugs becoming available and becoming clinically approved. Most of the approved drugs at the moment are antisense oligonucleotides and interference RNA products. But messenger RNA, of course, is also coming down the pike.
1:32
We know that messenger RNA works because it is essentially biological software, the cellular instructions to make any protein. The idea for therapeutic RNA is that one gets it into the cell of interest and that messenger RNA in the cytoplasm gets translated into therapeutic proteins by the ribosomes.

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RNA therapeutics: clinical applications and methods of delivery

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