Share these talks and lectures with your colleagues
Invite colleaguesWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at support@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support support@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support support@hstalks.com
We hope you have enjoyed this limited-length demo talk
This is a limited length demo talk; you may
login
or review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Multiple myeloma (MM) - Overview
- Multiple myeloma (MM) - Symptoms
- Multiple myeloma (MM) - Diagnosis
- Treatment of MM
- Treatment of MM - Drug resistance (DR)
- Bone marrow (BM) microenvironment
- Exosomes - Overview
- Exosomes in cancer and as biomarkers
- Exosomes - Isolation procedures
- Exosomes - Ultracentrifugation
- Exosomes - Gradient centrifugation
- Exosomes - Size exclusion chromatography
- Exosomes - Immunomagnetic isolation
- Exosomes - Exoquick kit
- Exosomes - Confirmation
- BM - Angiogenesis, Osteolysis, Drug resistance
- Exosomes in MM - Angiogenesis
- Investigating MM biology - Models
- Characterisation of MM exosomes
- Exosome cargo
- Role of hypoxia
- Hypoxia resistant MM cells stimulate angiogenesis
- miR135b cargo in MM exosome vesicles (EVs)
- miR340/365 in BM EVs: angiogenesis suppression
- Exosomes in MM - Osteolysis
- MM exosomes are taken up by osteoclasts
- MM exosomes stimulate osteoclasts
- MM exosomes support osteoclast survival
- MM exosomes stimulate osteoclasts via IL32
- MM exosomes inhibit osteoblasts
- Exosomes in MM - questions about drug resistance
- BMSC exosomes are picked up by MM cells
- Migration & proliferation of MM cells
- BMSC exosomes induce survival of MM cells
- BMSC induce resistance to bortezomib
- Drug resistance - Exosome cargo
- Healthy BMSC exosomes inhibit MM growth
- Role for IL6 and fibronectin in MM growth
- Role for miR15a in BMSC EVs in MM suppression
- miR146a transfer from MM cells to BMSC
- miR146a mimics increase MM viability & migration
- MM exosomes induce BMSC to CAF transition
- Role for miR21/146a
- Exosomes in MM - Conclusion (recap)
- Drug exposure increases exosome secretion
- Chemoexosomes & more heparanase on surface
- Heparanase in MM cells & cell cycle regulation
- Exosomes in MM - biomarkers
- Take home message
- Acknowledgments
Topics Covered
- Introduction to the biology of Multiple Myeloma
- The development of drug resistance in Myeloma
- The role of the bone marrow environment in drug resistance
- The concept of exosomes
- Points of attention when dealing with exosomes
- The role of exosomes within the bone marrow environment
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Menu, E. (2018, December 30). The role of exosomes in multiple myeloma development & drug resistance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 19, 2019, from https://hstalks.com/bs/3860/.Publication History
The role of exosomes in multiple myeloma development & drug resistance
Published on December 30, 2018
34 min
Hide