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Audio Interview

How and why neurons die in Alzheimer's disease?

Published on June 9, 2024   17 min

Other Talks in the Playlist: Research and Clinical Interviews

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Interviewer: Today I'm interviewing Professor Bart De Strooper, DRI Group Leader, UK Dementia Research Institute, UCL Queens Square Institute of Neurology, University College London, on Alzheimer's disease, MEG3, and the paper in science published on 14th of September 2023, on which Professor De Strooper is a senior author, titled: MEG3 Activates Necroptosis in Human Neuron Xenographs Modeling Alzheimer's Disease. A link to the paper accompanies this interview. Listeners are expected to have read at least the abstract and the conclusions of the paper before listening to this interview. Professor De Strooper, thank you for sparing the time. May I start by asking, in the first paragraph of the conclusion section you write, "Thus we suggest that neuronal death in AD is largely driven by necroptosis linking the loss of neurons to inflammatory processes that are upstream of this well-studied death pathway." Does that mean that in all cases of Alzheimer's disease necroptosis is involved, or that some manifestations of Alzheimer's disease
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How and why neurons die in Alzheimer's disease?

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