Interviewer: Professor Hughes, thank you for sparing the time this morning.
You're the head, as I understand of the London Lupus Center at the London Bridge Hospital.
And today, we're going to talk a little bit about
Lupus and Hughes' syndrome which was named after you.
And in particular, from the clinical point of view,
the unmet needs and opportunities that perhaps can open up
for the developers of drugs in addressing these conditions.
Let me start off by asking you,
have I got it right that in both conditions,
there is a trigger that sets off the condition but we don't know
for certain what is or what are the trigger or triggers?
Prof. Hughes: That's absolutely right.
There's a bit of genetics and a bit of environment in
many cases and the genetics is that we see members of
the family of Lupus patients who also have Lupus or
other what we call autoimmune diseases such as thyroid or MS
or rheumatoid. But there are, as you say,
environmental triggers that certainly start.
One of them is stress of all things.
It's not unusual to hear a patient first developing
acute Lupus after a bereavement or whatever.
The other one is sunshine, UV light,
UVB light specifically and often young women with Lupus,
their first presentation is on their honeymoon or on
holiday in a sunny place. They come back fatigue,
aches, and pains and sometimes rashes and that is now well-known.