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Other Talks in the Series: Vaccines

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I'm Derek O'Hagan. I work for GSK Vaccines. I research in Cambridge. I'm going to be talking about vaccine adjuvants. Although I'm an employee of GSK Vaccines, the presentation I'm going to make really reflects my experience across a number of companies, and it doesn't really express the policy of GSK.
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So in trying to define vaccine adjuvants and what they are, it's not an easy task to accomplish. Essentially, they are defined by what they do. They enhance the immune response to a vaccine antigen. So since there's no clear definition, there are many, many diverse substances in the literature that have been described as vaccine adjuvants, particularly in a pre-clinical setting. If we try to understand a little better those that have progressed to clinical trials, we can get a better appreciation of some of the materials, because a smaller percentage of advanced trials. And even a very small percentage of these have eventually been included in licensed vaccines. And these are the adjuvants I'm mostly going to focus on for obvious reasons. It's a very diverse area. There many materials, but I'm going to focus on those that have been most advanced.