Malaria vaccine development 1

Published on June 22, 2015   25 min

Other Talks in the Series: Vaccines

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Hello. My name's Ashley Birkett. I'm the Director of PATH Malaria Vaccine Initiative. And I'm going to give you an update today on current progress in malaria vaccine development efforts.
The presentation that I'm going to give is really divided into two main sections. First, introduction. I'm going to go through the burden of disease and recent trends in malaria morbidity and mortality, review the malaria life cycle and the vaccine opportunities that that provides, the biological evidence to support vaccine approaches. It's extremely important that we have evidence that it is possible to induce immunity and to support vaccine development efforts in humans. And then I'm going to switch over to vaccine development review, the current community goals with you, what the current targets are for vaccine development, the type of vaccines we're trying to develop, and the target efficacies. Efforts to increase the probability of success in reducing risks as we develop these products, and then the current progress against the malaria vaccine technology roadmap goals. Those are the community goals. And I'll review the goals and the current progress in achieving them. The introduction will come first.
This slide here gives you estimated spatial distribution of Plasmodium falciparum malaria around the world in 2010. Malaria in humans is caused by two main parasites, Plasmodium falciparum, which is responsible for most of the deaths around the world, and Plasmodium vivax. So as you can see from this slide here, the red areas indicate the areas of very high and intense malaria transmission. This is where you would see most of the cases. So clearly, West Africa is really a hotbed of falciparum transmission. And then the blue areas indicate more moderate levels of transmission. But you can see it's extremely widespread around the world And close to 100 countries in total populations are infected with malaria.