Innate ImmunityHost recognition and response in health and disease

Published May 2009 Updated August 2016 44 lectures
Prof. Siamon Gordon
Emeritus Professor, University of Oxford, Sir William Dunn School of Pathology, UK
Summary

Over the past decade, innate immunity has undergone an explosive development, placing it on a par with adaptive immunity. The innate response serves to protect the host against infection; it consists of evolutionarily ancient mechanisms able to recognize and respond rapidly, but non-specifically to diverse micro-organisms and injurious stimuli through... read moregenomically hard wired receptors, signals and products. It also serves to induce, regulate or suppress specific immune responses mediated by B and T lymphocytes, able to rearrange their surface receptors by somatic recombination, thus achieving slower but antigen specific protective responses. Excessive or insufficient innate immunity causes a wide range of inflammatory diseases, and provides targets for treatment, such as through antibodies to TNF. Toll-like receptors (TLR) play an important role in the activation of myeloid and antigen presenting cells, collaborating with opsonic and non-opsonic receptors. By shaping the immune response, innate immunity determines the efficacy of vaccination; in return it is influenced by interactions with specific antibodies and T Lymphocyte-derived cytokines.

The list of speakers represents a range of internationally prominent authoritative experts, who continue to make advances in the field. The coverage is comprehensive, with care to avoid unnecessary overlap.