0:00
This presentation
will be focused
on the Humoral arm of the
Innate Immunity
and the Acute Phase Response
will be discussed in the context
and in the perspective
of fluid phase
humoral pattern
recognition molecules.
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The innate immune system
includes a cellular
and a humoral arm.
Cell associated
pattern recognition molecules
are strategically located
on the cell surface
the Toll-like receptors
and co-receptors shown here
are also located
in the endosomal compartment,
a subset of the Toll-like receptor
and in the cytoplasm.
The latter include
NOD-like receptors,
RIG-like receptors
and not shown here,
AIM-like receptors.
This is where all the hype is,
cellular innate immunity.
But the innate immune system
also includes a humoral arm
which is generally represented
as a collection of weird molecules.
Humoral pattern
recognition molecules
include ficolins, collectins
such as mannose-binding lectin
and surfactant protein A and D.
Components of the complement
cascade and
short and long interactions.
In this presentation, I will focus
on the humoral arm
of the innate immunity
and on the humoral
pattern recognition molecules.
Using in particular, pentraxins
and along pentraxin PTX3,
as a paradigm for the logic
and the mode of action
and interplay
of the cellular innate immunity
of the humoral fluid phase
pattern recognition molecules.
