Humoral innate immunity and the acute phase response 1

Published on December 18, 2012 Updated on August 31, 2016   22 min

Other Talks in the Series: Cytokines

Other Talks in the Series: Innate Immunity

This presentation will be focused on the Humoral arm of the Innate Immunity and the Acute Phase Response will be discussed in the context and in the perspective of fluid phase humoral pattern recognition molecules.
The innate immune system includes a cellular and a humoral arm. Cell associated pattern recognition molecules are strategically located on the cell surface the Toll-like receptors and co-receptors shown here are also located in the endosomal compartment, a subset of the Toll-like receptor and in the cytoplasm. The latter include NOD-like receptors, RIG-like receptors and not shown here, AIM-like receptors. This is where all the hype is, cellular innate immunity. But the innate immune system also includes a humoral arm which is generally represented as a collection of weird molecules. Humoral pattern recognition molecules include ficolins, collectins such as mannose-binding lectin and surfactant protein A and D. Components of the complement cascade and short and long interactions. In this presentation, I will focus on the humoral arm of the innate immunity and on the humoral pattern recognition molecules. Using in particular, pentraxins and along pentraxin PTX3, as a paradigm for the logic and the mode of action and interplay of the cellular innate immunity of the humoral fluid phase pattern recognition molecules.

Humoral innate immunity and the acute phase response 1

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