Topics Covered
- Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection
- This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes
- Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them
- In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling
- Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis
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Talk Citation
Liu, Y. (2009, June 30). Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 25, 2023, from
https://hstalks.com/bs/1289/.
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Publication History
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Published on June 30, 2009
Financial Disclosures
- Prof. Yong-Jun Liu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.