My name is Charles Serhan,
and this is the second part
of our Henry Stewart talk series
under the innate immunity series.
And this is part two.
Part one was novel lipid mediators and
resolution of inflammation.
And since this is a very rapidly moving
area with a lot of excitement presently.
We thought it would be apropos to
update this with a second lecture,
which is entitled Resolvins Activate
A Systems Approach to Resolution.
And I will review the main
points from the first lecture
in case you don't have
an opportunity to listen to it.
My institution requires
that I show this disclosure
slide from our NIH
supported research grants.
Intellectual property has evolved.
That has led to licensing of patents
to both Bayer Healthcare and
to Resolvyx Pharmaceuticals.
And from this identification of novel
mediators that are involved in resolution,
I was a founder and
co founder of Resolvyx Pharmaceutical.
And the mission of this company is
to take this information in modules
from bench to clinic.
So, we now know that
there are many different
lipid mediators that play
a role in resolution.
And this slide depicts the main
sites of action of this new genus of
pro-resolvin lipid mediators and
their unique mechanism of action.
These, as you know from the first lecture,
are biosynthesized from
essential fatty acids.
And this genus constitutes several
families of structurally distinct
molecules that we'll go
over in this presentation.
The lipoxins, the resolvins,
and the protectins.
They act on both leukocytes, neutrophils,
depicted here in their diapedesis,
one of the first committed steps
to acute inflammatory response.
As well as stimulating pro-resolvin
responses on macrophages, for example,
and their ability to enhance the uptake
of apoptotic neutrophils by macrophages.
Clear them so that they can eflux and
clear debris as well to lymphatics.
So, these families of lipid mediators
have as their unique function
the ability to carry anti-inflammatory
as well as pro-resolvin actions.
Now, we've introduced
resolution indices to precisely
pinpoint the site of action and
to quantitate this pro-resolvin
action which had not been subject
to interrogation earlier.
And in the course of this, we've learned
that there are pro-resolvin mediators,
which we call the maresins,
that also act like resolvins that
are brought in late in
the resolution response.