Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts
Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins
The cellular component of this response causes a marked decrease in extracellular iron concentration
Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration
It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation
Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias
Ganz, T. (2009, May 31). Iron metabolism and innate immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2019, from https://hstalks.com/bs/1304/.
Published on May 31, 2009
Prof. Tomas Ganz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.