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1. Introduction
2. The global fungal infection problem
3. Candida albicans
4. Fungi, human disease and immune recognition
5. Temporal programme of immune responses
6. Questions and aspirations
7. Cell wall structure of Candida albicans
8. Pathogen-host tool box
9. Candida glycosilation mutants used
10. Candida mannan importance in various responses
11. Candida types affect cytokine production
12. Och1 in N-linked mannosylation, cytokine release
13. Creation of the "invisible fungus"
14. C. albicans phagocytosis is N-mannan-dependent
15. Binding to dendritic cells is N-mannan dependent
16. Inhibition of binding to dendritic cells (N-mannans)
17. Cooperativity in receptor-ligand interactions
18. TLR and lectin-like receptor complex synergism
19. Fonsecaea pedrosoi
20. Fonsecaea pedrosoi- a non-sufficient response
21. Artificial PRR co-stimulation cures infection
22. Importance of Candida chitin
23. Chitin- poly N-acetyl-b-D-glucosamine
24. CHS (chitin synthase) genes of C. albicans
25. High-chitin C. albicans cells are tolerated in vivo
26. Chitin blocks PMNC recognition of C. albicans
27. Effects of Caspofungin treatment
28. Chitin doesn't block PBMC Salmonella recognition
29. Chitin doesn't block recognition via TLR2 or TLR4
30. Dectin-1 does not bind chitin directly
31. Morphogenesis importance in immune responses
32. Hyphae can survive and fight phagocytosis
33. Candida morphogenesis and immune recognition
34. Hyphae specifically induce Th17 response
35. Hyphae specifically induce IL-1beta inflammasome
36. Immune tasting of Candida albicans
37. A memorable metaphor
38. Summary
39. Acknowledgments

Topics Covered

• Immune recognition of fungi
• Fungal infections are serious challenges in the clinic
• The innate immune system has a pre-eminent role in containing fungal infection
• Cell wall mutants of Candida can be used to help discover the nature of the recognition mechanisms
• Combining pattern recognition mechanisms can greatly amplify immune response
• Candida mannan in recognition, phagocytosis and activation of immune responses
• Candida chitin importance in cell wall integrity and immune responses
• Candida albicans yeast-hypha morphogenesis: activation and resistance to immune responses

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Cell Biology
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on July 9, 2012

Financial Disclosures

• Prof. Neil Gow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.