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1. Introduction
2. Evolving immune response
3. Interferons
4. The antiviral effect of type 1 IFN
5. IFNs induce various pathways
6. IFN alpha and beta in an infected cell
7. Flexibility of IFN induction
8. Viral infections
9. Activation of immune response in viral infection (1)
10. Immunoregulatory effects of type 1 IFN
11. Direct antiviral vs. immunoregulatory effects of IFN
12. NK cells during viral infections
13. NK cells - innate lymphocytes in defense
14. Regulation of NK cell responses by IFN and IL12
15. Activation of immune response in viral infection (2)
16. IFN signaling
17. STAT1 in defense against infection
18. Evidence of STAT1-independent IFN signaling
19. Evidence of STAT3-independent IL-6 signaling
20. Type 1 IFN signaling
21. Conditioning model for regulating type 1 IFN effects
22. STAT regulation mechanisms
23. Cell and cytokine responses to LCMV infection
24. Examining STAT expression in NK cells
25. STAT expression in NK cells
26. STAT expression and activation during infection
27. Examining STAT responsiveness
28. STAT responsiveness to type 1 IFN
29. Contributing factors to STAT1 induction
30. STAT1 and STAT2 in IFN gamma response
31. IFN gamma expression and STAT4 activation
32. Blocking IFN gamma induction
33. Type 1 IFN receptor association
34. Genes and proteins regulating type 1 IFN effects
35. Clinical use of IFN
36. Acknowledgements

Topics Covered

• Evolving immune response
• Interferons
• Antiviral effects
• IFNalfa/beta induction
• Role of IFNalfa/beta in fighting off viruses and infection
• Activation of immune response cascades during viral challenges
• Immunoregulation
• NK cells during viral infections
• Innate lymphocytes in defense
• Regulation of NK cell responses by IFNalfa/beta and IL-12
• IFN signaling
• STAT1 in defense against infection
• Kinetics of cell and cytokine responses to LCMV infections
• STAT expression in NK cells
• Type 1 IFN receptor association
• Gene expression and protein-protein interactions for regulating type 1 IFN effects
• Interferon treatment
• Interferon ablation

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Biron, C. (2009, June 30). Type I interferons in innate immunity to viral infections [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 23, 2025, from https://doi.org/10.69645/MKTL7276.
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Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Christine Biron has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.