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Printable Handouts
Navigable Slide Index
- Introduction
- Lipid mediators
- Resolution of acute inflammation
- Schematic and histological sequence of events
- Glossary: from PUFA precursors to lipid mediators
- "Classic" lipoxin-generating pathways
- Lipoxins and ATL in resolution of inflammation
- Lipoxins counter-regulate signs of inflammation
- Production of 15-epi-lipoxins
- Rapid screening: fast pace to stable analogs
- 15-(R/S)-methyl LXA4 analog
- LX and ATL deficiencies in human disease
- From acute phase to resolution phase
- Outcome of inflammation: complete resolution
- Murine dorsal air pouch
- LC-MS-MS based profiling of lipid mediators
- LC-MS-MS results: 18R-HEPE
- Resolvin E1 stops PMN infiltration
- Biosynthesis of resolvin E1
- Identification of novel lipid mediators
- RvE1 in human plasma: mediator lipidomics
- Resolvins: actions of E series resolvins
- Resolvin E1: stereospecific total organic synthesis
- Localized aggressive periodontitis (LAP)
- Rabbit model for LAP
- RvE1 protects from inflammatory bone loss
- Receptor screening for counter-regulatory signals
- Specific GPCRs for resolvin E1 actions
- RvE1 acts via two distinct leukocyte GPCRs
- RvE1 transformation
- 19-para-fluoro-phenoxyl RvE1
- DHA precursor to resolvins and protectins
- Resolvins: actions of D series
- RvD1 and ATRvD1: human PMN transmigration
- Resolvins E and D series reduce murine peritonitis
- Protectins: DHA-derived 17S-series
- Biosynthesis of protectin D1/ neuroprotectin D1
- PD1 stops leukocyte infiltration
- Temporal-differential analyses of resolution
- Resolution in quantitative terms
- Upregulation of CCR5 during resolution
- Resolvins and protectins in humans - summary
- Resolvins and PD1 identified in murine kidney
- PD1 and RvD1
- Activity scores of mice treated with PD1 or RvDs
- Discovery of a deficiency disease in rats
- Normal vs. curled tail
- Summation: some key points to remember
- Resolvins and known pharmacological agents
- Resolvins & protectins- summary
- NIDCR
- Laboratory of professor Charles N. Serhan
Topics Covered
- Complete resolution of the acute inflammatory response and its return to homeostasis is essential
- Efforts to identify and characterize the cellular and molecular mechanisms that govern resolution of self-limited inflammation
- Systems approach with temporal analysis of the evolving inflammatory exudates using unbiased mediator lipidomics/informatics, proteomics, and cellular traffic with murine resolving exudates
- Novel endogenous pathways of local acting mediators that are dual acting, and that are both anti-inflammatory and pro-resolving
- Biosynthesis and actions of "resolvins" and "protectins"
- E-series resolvins and D-series resolvins
- Actions of neuroprotectin D-1
- Biosynthesis of aspirin-triggered lipid mediators and their impact in regulating acute inflammatory responses
- The resolution of acute inflammation is an active process that can be accelerated
Links
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Talk Citation
Serhan, C. (2020, May 1). Novel lipid mediators in resolution of inflammation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/YMBP5943.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Charles Serhan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.