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Printable Handouts
Navigable Slide Index
- Introduction
- Inflammation in the CNS
- Macrophage populations of the CNS
- Perivascular macrophages
- Regulation of the microglia phenotype
- Microglia sensors of pathology
- Models of macrophage activation
- Acute vs. persistent stimuli
- Inflammation in Alzheimer's disease
- A model of chronic neurodegeneration
- Prion pathology at 13 weeks
- Evolution of prion disease
- Cytokine profile in prion disease
- Clearance of apoptotic cells
- Neuronal death in prion disease
- Synaptic loss revealed by synaptophysin staining
- Differences between prion and Alzheimer's disease
- Communication in sickness behavior
- Prion diseased mice injected with endotoxin
- The profile in prion disease and LPS challenge
- Microglia priming in prion disease
- Priming in the prion diseased parenchyma
- Activated caspase-3 immunocytochemistry
- Are prion models relevant to Alzheimer's disease?
- Infection in Alzheimer's disease
- Clinical studies
- Systemic infections and rates of decline
- Systemic infections and sickness behavior
- Systemic infections and cognitive decline
- Concluding remarks
- Acknowledgements
Topics Covered
- Macrophage populations in the brain
- Regulation of brain macrophage-microglia phenotype
- Inflammation in Alzheimer's disease
- Prion disease, a model of chronic neurodegeneration
- Behavioural assays
- Impact of systemic infections/inflammation on the brain
- Interactions between systemic inflammation and brain disease
- Microglia switching
- Relevance to Alzheimer's disease?
- Impact of systemic infections on Alzheimer's disease progression
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Talk Citation
Perry, V.H. (2009, June 30). Innate immunity in the brain in health and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/TAUG2813.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. V. Hugh Perry has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.