Topics Covered
- Nuclear receptors comprise a superfamily of ligand- and signal-dependent transcription factors that regulate diverse aspects of reproduction, development, metabolism and immunity
- Recent studies have demonstrated that a subset of nuclear receptors can co-ordinately regulate aspects of inflammation and metabolism that impact on the development of atherosclerosis and type 2 diabetes by inhibiting transcriptional responses to toll like receptors
- The nuclear receptor co-repressor NCoR plays a key role in maintaining inflammatory response genes in a repressed state under basal conditions
- PPARg inhibits inflammatory responses by preventing the removal of NCoR from target genes
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Talk Citation
Glass, C. (2009, May 31). Nuclear receptors at the crossroads of inflammation and atherosclerosis [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 2, 2022, from
https://hstalks.com/bs/1297/.
Publication History
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Published on May 31, 2009
Financial Disclosures
- Prof. Christopher Glass has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.