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Printable Handouts
Navigable Slide Index
- Introduction
- Overview of lecture
- Why leprosy?
- Key facts
- Leprosy spectrum
- Leprosy clinical spectrum
- WHO cardinal signs of leprosy (2012)
- The disease spectrum
- Indeterminate leprosy
- Presentation of leprosy
- Sites where enlarged nerves can be felt
- Examining nerves in a patient
- Neurological evaluation (1)
- Nerve damage
- Neurological evaluation (2)
- WHO disability grading
- Peripheral nerve damage (1)
- Peripheral nerve damage (2)
- Peripheral nerve damage (3)
- The eye in leprosy (1)
- The eye in leprosy (2)
- Diagnostic tests
- Serological tests
- Serological tests and PCR
- Nerve and skin biopsy
- Bacteriological index
- Diagnosis of leprosy
- Treatment of leprosy
- Leprosy MDT
- Chemotherapy
- Adverse effects
- MDT success story
- Checklist for new patients
- MDT treatment - endpoints
- U-MDT
- Screening contacts and propylaxis
- Immunological complications
- Type 1 (reversal) reactions
- Treatment of type 1 reactions
- Neuritis
- Type 2 (ENL) reactions
- Clinical features of ENL
- ENLIST ENL severity scale (EESS)
- Treatment of ENL (1)
- Treatment of ENL (2)
- Household costs
- Monitoring Adverse effects of steroids
- Studies on treatment of type 1 reactions
- Type1 reactions – second Line agents
- Steroid treatment of reactions summary
- Neuropathic pain (1)
- Neuropathic pain (2)
- Summary
- Thanks
- References
Topics Covered
- Leprosy disease Ridley-Jopling spectrum
- Clinical signs of leprosy and leprosy presentation
- Diagnostic tests for leprosy
- Leprosy antibacterial treatment
- Type 1 reactions
- Erythema nodosum leprosum
- steroid treatment
- Neuropathic pain
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Lockwood, D.N. (2024, July 23). Leprosy: clinical features and treatment [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2024, from https://doi.org/10.69645/UCKO2872.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Diana N.J. Lockwood has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Leprosy: clinical features and treatment
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Other Talks in the Series: Neglected Tropical Diseases
Transcript
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0:00
Hello. It's a great pleasure
to be talking about leprosy.
I'm Diana Lockwood,
and I'm a Professor
of Tropical Medicine.
I've spent a lifetime
working on leprosy.
I want to share the interest
and challenges of leprosy
with you in this talk.
0:18
In this talk, I'm going to talk
about the clinical
signs of leprosy.
That's very important
because leprosy is
diagnosed clinically
on the basis of the skin
lesions and the nerve lesions.
I'm going to talk about the
presentation of leprosy,
the different range
of skin lesions
that people can present with
and I'm going to talk about
the examination of the skin
and the nerve that's important
to diagnose leprosy.
We're fortunate
because leprosy is a
very treatable mycobacterial
infection and we have
antibiotics that work very
well and give a good outcome
in terms of treatment with
a very high cure rate.
However, leprosy
is complicated by
these immunological
events called reactions,
and these are when patients have
episodes of increased
inflammation
and they present as
new inflammation in
the skin lesions and
inflammation in the nerve,
which is called neuritis.
Then finally, there's the
prevention of disability
and this is very
important in leprosy
because leprosy is a
disabling disease.
1:26
People often ask why did I
get interested in leprosy?
The answer is because I had
a gap year between
school and university,
and I volunteered in a leprosy
hospital in India in 1975.
When I was at the hospital,
the man running
the hospital said
leprosy is a really
interesting disease and
I could see it was
because they were
just getting new antibiotics
to treat leprosy.
But I could also see
that you could prevent
a lot of the nerve
damage by helping people
look after their hands and feet,
and so getting people
to do self-care.
After that, I then
travelled home over land.
The map shows my
journey across Pakistan
and then around Afghanistan
and then across Iran
and then up to Turkey.
I did this as a
single 18-year-old
and I had a fascinating time.
Of course, Afghanistan
has completely changed
since I was there in
1975, as has Iran.
That gave me a lot of interest
in leprosy and interest in
travel and I'm very
glad that I've been
able to combine the two.
I came back to Birmingham
and then I trained
in medicine there.
Obviously, I was interested
in infectious diseases
and I then did student
projects on leprosy
because I knew that I wanted
to do research on leprosy.
I then moved to London and
I trained in general
medicine and
specialised in
infectious diseases
and then super-specialised
in leprosy.
I did research on leprosy and
that took me back to India.
Then I was very lucky
because in 1994
the one NHS leprologist retired
and so I was able
to take his post
and be the UK leprologist.
I then combined a career
in medicine and research
because I did my academic work
at the School of Hygiene
and Tropical Medicine.
What I've done is a lot
of work on trying to
improve outcomes for
leprosy patients.