Mycobacterium ulcerans disease: Buruli Ulcer

Published on December 31, 2019   32 min

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Hello there. This is Richard Odame Phillips from the Department of Medicine and Kumasi Center for Collaborative Research at the Kwame Nkrumah University of Science and Technology in Ghana. This talk is on Mycobacterium ulcerans disease, commonly called Buruli ulcer.
The outline of my talk is on this slide and it will cover what Buruli ulcer is, the history, epidemiology and transmission, biology, pathogenesis, clinical manifestation and differential diagnosis, diagnostic confirmation, treatment, complications, prevention, and control strategy.
Buruli ulcer is an infectious disease caused by Mycobacterium ulcerans. It's one of three mycobacteria diseases common in humans. They are in the same group as those that cause tuberculosis and leprosy.
Regarding the history of Buruli ulcer in 1897, Sir Alfred Cook recorded skin lesions that looked like Buruli ulcer. In 1920's, Kleinschnmidt also found similar lesions that way undermined and looked like Buruli ulcer in Uganda and Zaire. In 1948, MacCalum et el managed to achieve the first culture or Mycobacterium ulcerans, and this occurred by chance when his incubator that was set at 37 degrees Celsius broke down. Typically, Mycobacterium ulcerans will grow at a lower temperature between 30-33 degrees. In 1948 to the '70's, several animal model studies were carried out. Of note, the Uganda Buruli Group carried out large epidemiological studies in the Buruli district in Uganda. In 1965, the leprosy missionary workers in Zaire suggested that a toxin was the cause of these lesions, but from 1965, very few cases were reported on Buruli ulcer until we recorded more cases in the West African region. Since then, most of the cases have been mentioned in the West African region, but not in Uganda or Zaire like it was in the '60's.

Mycobacterium ulcerans disease: Buruli Ulcer

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