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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- What is Buruli ulcer?
- History
- Epidemiology (1)
- Epidemiology (2)
- Who gets the disease?
- Annual cases of Buruli ulcer
- Transmission
- Introduction into skin
- Water insects: M. ulcerans carriers
- Transmission in Australia
- M. ulcerans biology
- Colony appearance
- M. ulcerans toxin: Mycolactone
- Mycolactone-encoding plasmids
- Effect of mycolactone
- M. ulcerans pathology
- M. ulcerans pathogenesis
- Histology
- Clinical manifestation
- Papule
- Nodule
- Plaque
- Oedema
- Ulcer (1)
- Ulcer (2)
- Differential diagnosis for non-ulcers disease
- Differential diagnosis for ulcers
- Sample collection methods
- Laboratory confirmation
- Past treatment
- Principles of BU management
- WHO treatment guidance
- Antibiotic combinations (8 weeks)
- Considerations for Streptomycin
- Considerations for Clarithromycin
- Considerations for Moxifloxacin
- Effect of treatment
- Side effects
- Paradoxical reactions (1)
- Paradoxical reactions (2)
- Paradoxical reactions (3)
- Wound care and surgery
- Complications
- Contracture in ill-managed wounds
- Amputation
- Eye complications
- Prevention
- Control strategy
- Community-level activities
- Health education
- Education should be increased
- Strengthening the health system
- Standardized case management
- Supportive activities
- New approach to skin NTDs
- Thank you for listening
Topics Covered
- Buruli ulcer: history, epidemiology and transmission
- Clinical manifestation and differential diagnosis
- An explanation of the current diagnostic methods
- An update on treatment and clinical care
- The current Buruli ulcer control strategy
- Implications of late treatment
- An integrated approach to control of disease
Links
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Talk Citation
Phillips, R.O. (2019, December 31). Mycobacterium ulcerans disease: Buruli Ulcer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/IKNL9938.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Richard Odame Phillips has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
HSTalks is pleased to grant unrestricted complimentary access to all lectures in the series Neglected Tropical Diseases. Persons not at a subscribing institution should sign up for a personal account.
Other Talks in the Series: Neglected Tropical Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Hello there. This is Richard Odame Phillips from
the Department of Medicine and Kumasi Center for Collaborative Research
at the Kwame Nkrumah University of Science and Technology in Ghana.
This talk is on Mycobacterium ulcerans disease,
commonly called Buruli ulcer.
0:22
The outline of my talk is on this slide and it will
cover what Buruli ulcer is, the history,
epidemiology and transmission, biology, pathogenesis,
clinical manifestation and differential diagnosis,
diagnostic confirmation, treatment, complications,
prevention, and control strategy.
0:48
Buruli ulcer is an infectious disease caused by Mycobacterium ulcerans.
It's one of three mycobacteria diseases common in humans.
They are in the same group as those that cause tuberculosis and leprosy.
1:06
Regarding the history of Buruli ulcer in 1897,
Sir Alfred Cook recorded skin lesions that looked like Buruli ulcer.
In 1920's, Kleinschnmidt also found similar lesions
that way undermined and looked like Buruli ulcer in Uganda and Zaire.
In 1948, MacCalum et el managed to achieve the first culture or Mycobacterium ulcerans,
and this occurred by chance when
his incubator that was set at 37 degrees Celsius broke down.
Typically, Mycobacterium ulcerans will grow at a lower temperature between 30-33 degrees.
In 1948 to the '70's,
several animal model studies were carried out.
Of note, the Uganda Buruli Group carried out
large epidemiological studies in the Buruli district in Uganda.
In 1965, the leprosy missionary workers in
Zaire suggested that a toxin was the cause of these lesions,
but from 1965, very few cases were reported on
Buruli ulcer until we recorded more cases in the West African region.
Since then, most of the cases have been mentioned in the West African region,
but not in Uganda or Zaire like it was in the '60's.