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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Genus Flavivirus
- Dengue viruses
- Transmission and maintenance cycles
- Principal vector: Aedes aegypti
- Secondary vectors: Aedes albopictus/Ae. scutellaris
- Dengue virus infection and dissemination
- Spectrum of clinical illness associated with Dengue
- Clinical characteristics of Dengue fever
- Differential diagnosis of Dengue and DHF
- Dengue case classification & severity levels
- Dengue Shock Syndrome (DSS)
- Pathophysiologic changes of vascular leak syndrome
- Management of Dengue Hemorrhagic Fever patients
- Laboratory diagnosis: serologic assays
- Laboratory diagnosis: direct detection assays
- Human viremia & immune response to Arboviruses
- Why severe Dengue disease?
- Hypotheses on pathogenesis of severe Dengue fever
- Antibody-dependent enhancement of Dengue virus
- Facts about ADE
- Evidence for virus virulence
- Case studies of epidemic Dengue
- Epidemic history in Puerto Rico 1963-2000
- Epidemic Dengue 4 in Puerto Rico, 1981-1994
- DENV-4 Clade distribution by year
- History of Dengue transmission in Puerto Rico
- Lineage-replacement & DENV-2 epidemic 1994
- Viral determinant of epidemiological fitness
- Support of virus virulence H0 (1)
- Support of virus virulence H0 (2)
- Risk factors for severe disease
- Hyperendemicity
Topics Covered
- Basic biology and epidemiology of dengue viruses
- Clinical and laboratory diagnosis
- Risk factors for severe disease and epidemic transmission
- Case studies of dengue epidemic
Links
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Talk Citation
Gubler, D.J. (2020, June 30). Dengue: biology, diagnosis and pathology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/FDKW6625.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Emeritus Duane J. Gubler has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Dengue: biology, diagnosis and pathology
Published on June 30, 2020
27 min
HSTalks is pleased to grant unrestricted complimentary access to all lectures in the series Neglected Tropical Diseases. Persons not at a subscribing institution should sign up for a personal account.
Other Talks in the Series: Neglected Tropical Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Duane Gubler.
I'm a professor emeritus at the Duke-NUS Medical School in Singapore.
I have a long career in dengue.
I've been working on dengue for nearly 50 years.
I spent 25 years at the Centers for Disease Control and
Prevention prior to going to Hawaii and to Singapore.
I was the founding director of the CDC dengue branch in Puerto Rico.
0:29
Today I'm going to be talking about dengue
and tell you everything you want to know about dengue.
I'll begin by talking very briefly about the biology and transmission cycle.
Then also briefly talk about the clinical presentations and diagnosis,
a bit about pathogenesis,
and then focus on the changing epidemiology that we're seeing in
the past 30-40 years and finish by talking about prevention and control.
0:58
The dengue viruses belong to the family flaviviridae, the genus Flavivirus.
As you can see from this first slide,
there are a number of flaviviruses but
the groups that we're interested in are the tick-borne and the mosquito-bornes.
The dengue viruses belong to the mosquito-borne viruses.
You can see them up in the right-hand corner there,
very closely related to Zika and Spondweni virus and also through
the Culex flaviviruses that includes Japanese encephalitis and West Nile.
1:32
There are four serotypes- antigenic types- of dengue viruses.
We call them dengue 1,
2, 3 and 4.
They're antigenically distinct, but they're really considered one virus.
A fifth serotype has recently been described from Malaysia.
It's not documented that it is a fifth serotype yet that's why I have a question mark by it.
It's very closely related to dengue type 4.
So we're not sure if it's a variant of dengue 4 or whether it's a serotype.
The dengue viruses, like all flaviviruses,
have an open reading frame.
There are 10 proteins that make up that reading frame,
three structural proteins and seven non-structural proteins.
All of these play an important role in the biology of the dengue viruses.