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Printable Handouts
Navigable Slide Index
- Introduction
- Why do we think it is feasible to eliminate canine rabies?
- Lessons from Latin America
- Challenging the dogma
- Reservoirs of infection
- Rabies reservoirs in the Serengeti: No evidence for independent wildlife cycles
- Rabies reservoirs in the Serengeti
- Testing the hypothesis through a large-scale intervention
- What level of vaccination coverage is needed?
- How many dogs do we need to vaccinate?
- Indiscriminate culling is particularly ineffective in controlling rabies
- Theoretical predictions supported by empirical data
- Can we reach 70% coverage?
- Dogs of all ages can be safely vaccinated
- Most dogs are owned (and have names)
- …and this applies across Africa and Asia
- Rabies prevention in Sri Lanka
- How do we achieve “Zero By 30”?
- Catalysing action
- How can research support elimination goals?
- Real-time rabies surveillance: portable whole genome sequencing
- Research relevant to vaccine delivery
- Action on rabies can support progress to sustainable development goals
- One Health interventions that target dogs
- Can we eliminate rabies?
- Thank You!
Topics Covered
- Prevention and control of rabies in Latin America
- Reservoirs of infection in the Serengeti
- Transmissibility (R0) of rabies
- Effective vs. ineffective methods for rabies control
- “Zero by 30” initiative
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Talk Citation
Cleaveland, OBE, FRS, S. (2020, August 31). Eliminating human rabies deaths: targeting the elimination of rabies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/STMB5660.Export Citation (RIS)
Publication History
Financial Disclosures
- The rabies research project in the Serengeti receives an annual donation of rabies vaccine from MSD Animal Health to support mass dog vaccination.
Eliminating human rabies deaths: targeting the elimination of rabies
Published on August 31, 2020
33 min
HSTalks is pleased to grant unrestricted complimentary access to all lectures in the series Neglected Tropical Diseases. Persons not at a subscribing institution should sign up for a personal account.
Other Talks in the Series: Neglected Tropical Diseases
Transcript
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0:05
Why do we think it is feasible to eliminate canine rabies?
I'm going to be presenting some of the evidence globally,
but also focusing on some of our own work in East Africa.
This has been an area of particular interest because of
the questions around the epidemiology of the disease in
multi-hosting complex natural communities
where you have many different mammalian species.
0:27
But, if we first looked at Latin America,
we can learn an awful lot about some of
the key factors in successful control and elimination.
From having been endemic throughout the region,
today human rabies transmitted from dogs is only
reported in seven of 35 countries of Latin America.
A real key factor in success has
been investments made in mass dog vaccination.
If we compare the expenditure on rabies control and prevention in Asia and Latin America,
in Asia for example,
we see that expenditure per capita is actually
very high and it's higher than in Latin America.
But most of this is focused on the provision of a human vaccine for PEP,
very literally is spent on dog vaccination.
While PEP can save lives,
it's still not reaching those most in need and we're still seeing
37 or so thousand human deaths every year.
In contrast, if you look at the situation in Latin America,
fairly modest investments in dog vaccination,
and this is equivalent to about 20 percent of the total costs of
rabies control has been sufficient to bring dog rabies closed to elimination.
This has been achieved even with a lower per capita spent on human vaccine than in Asia.