Hi, my name is Susan Hua. I'm an associate professor in the discipline of
pharmacy and the head of
the Therapeutic Targeting Research program at the University of Newcastle.
The focus of this lecture is on drug delivery to the colon.
Multiple pathologies localised in the colon require specific delivery systems,
which will be considered in this lecture.
This slide shows an outline of the lecture.
The first part will briefly cover the functional anatomy of
the gastrointestinal tract and the general principles of drug absorption.
This will then lead to the physiological considerations for drug delivery to the colon.
Both oral and rectal drug delivery will be discussed.
However, the lecture will focus more on the oral route
as it is the main route for colon specific drug delivery.
I will then discuss the changes in the physiology
of the gastrointestinal tract in colonic diseases,
focusing on inflammatory bowel disease or IBD,
gastrointestinal infections and gastrointestinal surgery.
The final parts of the lecture will cover
the conventional approaches to colon specific drug delivery,
novel colon specific drug delivery systems,
and the translational development aspects of novel formulations.
Now to part one of the lecture on
the general anatomy and physiology of the gastrointestinal tract.
The gastrointestinal tract or GI tract,
is a muscular tube that is approximately nine meters in length with varying diameters.
The gastrointestinal tract is divided into the upper and lower tract.
The upper gastrointestinal tract consists of the mouth, pharynx,
oesophagus, stomach, and the first part of the small intestine,
also known as the duodenum.
The lower gastrointestinal tract includes the other parts of the small intestine,
that is the jejunum and ileum and all of the large intestine.
The small intestine is
the longest at approximately six meters in length and the most convoluted part
of the gastrointestinal tract.