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Printable Handouts
Navigable Slide Index
- Introduction
- Research contributions (past and present)
- Outline
- Bio-transporters
- Key transporters
- P-glycoprotein transporters
- P-gp transporters in brain
- Key findings on P-gp inducers for drug-drug interaction
- Nanoparticle-mediated P-gp inhibitor drug delivery in multidrug resistant cancer
- Reversing the direction of drug transport
- Breast cancer resistance protein (BCRP)
- Recent update of the ABCG2 Inhibitors
- Inhibitory effect of curcumin on the ACB4-mediated (3H)-doxorubicin efflux
- Recent update of the ABCG2 inhibitors
- P-gp (MDR1/ABCB1) and breast cancer resistance-protein (BCRP/ABCG2) interaction
- BPCR effect on atypical multidrug resistance protein (MRP)
- Transporters for cancer therapy
- Encorafenib is a promising drug inhibitor
- Solute carrier (SLC) transporters
- Organic anionic transporters
- Functions
- Anion transporters
- Inhibitors of OAT1
- Effect of (−)-epigallocatechin-3-gallate (EGCG) on human and renal OAT1 and OAT3
- Antibiotics interaction with SLC
- Organic cationic transporters (OCTN2)
- OCTN2-mediated L-carnitine transporter
- Facilitative glucose transporters (GLUTs)
- Apical bile salt transport (ASBT/SLC10A2)
- Monocarboxylate transporter-1 (MCT1/SLC16A1)
- Thank you
Topics Covered
- Biotransporters in drug delivery
- Classification of transporters
- P-glycoprotein transporters
- Transporters for cancer therapy
- Solute carrier transporters
- Facilitative glucose transporters
- The substrates and inhibitors of different transporters
- Effect of transporters in drug delivery
- Pharmacological applications
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Shende, P. (2022, July 31). Transporters in drug delivery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 14, 2024, from https://doi.org/10.69645/CNCF8326.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Pravin Shende has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Drug Delivery
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. My name is
Dr. Pravin Shende,
I am Professor and PG
Chairperson at SVKM's and NMIMS,
Shobhaben Pratapbhai
Patel School of
Pharmacy and
Technology Management,
Mumbai, India.
0:17
This is my research contributions
and accomplishments.
0:22
It's my pleasure to
introduce the topic
regarding different transporters
in drug delivery systems.
I am going to tell you
about multiple approaches
for delivery via transporters
present in the human body.
Outline on the substrates
and inhibitors of
transporters that
affect delivery
and their pharmacological
applications.
0:50
Most transporters show a
site-specific expression
which provides ideal targets
for drug delivery to
increase uptake at
specific site or enhanced
permeation across
biological barriers
such as blood-brain barrier.
In bio-transporters,
movement of drugs from
one biological barrier to
another side of the cell is
guided via transport mechanism.
Membrane-associated
proteins that govern
the transport of solutes,
for example, drugs and
other xenobiotics into
and out of the cells.
Transporters can play a
vital role in determining
the drug concentrations in
systemic circulation
and in cells.
The two major super families of
membrane transporters are
ATP Binding Cassette,
ABC and Solute Carrier
SLC Super Families.