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Hello, my name is Kishor Wasan.
I'm currently a Distinguished
University Scholar
and Adjunct Professor in
the Department of
Biological Sciences in
the Faculty of Medicine at the
University of British Columbia,
as well as the co-director
and co-founder
of our Neglected Global
Diseases Initiative.
I was a professor
at UBC and then was
a Dean of a pharmacy
school on the prairies,
retired from there
and have now come
back to my former university.
Today I'd like to
talk to you about
a very neat and niche area of
how we can enhance
the oral absorption of drugs
and its bioavailability.
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The outline for my presentation
today is the following,
what is lymphatic transport?
What are the drug properties
required for
lymphatic transport?
What did become the
characteristics
of lymphatic transport?
Then I wanted to give you
some key actual examples
where drugs that are
your package into
lipid packages that
can enhance lymphatic
transport are done
or drugs themselves or nutrients
that had the
characteristics that make
them ideal for
lymphatic transport.
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Over the years, a number of
different research groups
have worked together in
developing key principles and
properties that would
make a drug candidate,
a good candidate for
lymphatic transport.
Kind of like how we have
the Lipinski rule of five,
we've come down with
four fundamental
critical properties
that seemed to be
required in order for
a drug to be able to
absorb using the mechanisms
of lymphatic transport.
The first one is the cLog
P being greater than five,
that is the optimal
water coefficient.
The idea here is that a drug
that's very lipophilic,
water-loving in its properties
with greater of 5:1
ratio is something that
would be viable for
lymphatic transport.
The second is
triglyceride solubility.
That a drug has a
high solubility and
triglycerides usually greater
than 50 milligrams per mil,
and it's usually a function of
medium-chain triglycerides
and long-chain triglycerides.
A third factor is the ability of
the drug to partition
into chylomicrons.
Chylomicrons are
triglyceride-rich lipoproteins,
and usually anywhere between
40% distribution into
chylomicrons makes this an
ideal candidate for
lymphatic transport.
Finally, most drugs
usually have to be
small molecules and have
a molecular weight
less than 500.
