My name is José Luis Arias,
from the University of Granada, Spain.
It is my pleasure to start the talk on vaginal and uterine drug delivery,
where we will analyze the need for drug delivery systems to these groups.
The materials used for developing
those drug delivery systems and some relevant specifics or peculiarities on the subject.
Before starting the talk,
let me thank you for the opportunity given to
share my views on vaginal drug delivery systems.
Nanocarriers are drug microns in the submicron size that have been under
extremely extensive research in an attempt to
fundamentally change the conventional strategies for drug administration.
Present advances in pharmaceutical nanotechnology have allowed the creation of
versatile nanosystems such as nanoparticles, vesicles, and nanomedicines.
That can be engineered to overcome barriers imposed by
the organisms and delivery date therapeutic cargo
in a temporally and in spatially controlled manner.
Enable deep penetration into the body tissues,
efficient internalization at the cellular level,
and controlled drug release.
Any pharmacologically active substance,
regardless of its molecular weight,
hydrophilic character and stability,
or any other physicochemical properties including small molecule drugs,
peptides, proteins, and DNA and RNA,
can be very easily loaded into
an adequate nanoparticle for introduction by almost any route of drug administration,
to achieve efficient delivery to the site of index.
Hence superior chemical and biological stability,
ability to shield the loaded drug from degradation sources.
A smartly tuned drug pharmacokinetics and biodistribution are
a few examples to name among
the unique features offered by these drug delivery platforms.