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Hi, my name is Susan Hua,
and I'm an associate professor in the discipline of pharmacy and the head of
the therapeutic targeting research program at the University of Newcastle.
The focus of this lecture is on gastrointestinal drug delivery,
which will be considered both as a route for systemic drug delivery
and for treating local gastrointestinal diseases.
This slide shows an outline of the lecture.
Firstly, I will discuss the general anatomy of
the gastrointestinal tract, and
the general principles of drug absorption in the gastrointestinal tract.
This will be followed by a more detailed discussion on
the physiological and pharmaceutical considerations influencing drug delivery,
as well as the drug delivery approaches for each
of the main routes for gastrointestinal drug delivery.
The gastrointestinal tract, or GI tract,
is a muscular tube that is approximately nine meters in length with varying diameters.
The gastrointestinal tract is divided into the upper and lower tract.
The upper gastrointestinal tract consists of the mouth, pharynx,
esophagus, stomach, and the first part of the small intestine,
also known as the duodenum.
The lower gastrointestinal tract includes the other parts of the small intestine,
that is the jejunum and ileum, and all of the large intestine.
The large intestine is the distal part of
the gastrointestinal tract and has three main segments,
the cecum, the colon, and the rectum.
The colon can be divided into four parts;
ascending, transverse, descending, and sigmoid.
The main functions of the gastrointestinal tract are the digestion of food,
absorption of nutrients, and excretion of waste products.
The gastrointestinal tract is also a common route for drug administration,
with the main routes being sublingual,
buccal, oral, and rectal.
These routes will be the focus of this lecture on
gastrointestinal drug delivery as a route for drug administration.