Micellar drug delivery

Published on February 27, 2020   33 min
0:00
Hello, I'm Francesco Cellesi, Associate Professor at the Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta", Politecnico di Milano in Italy. The title of this presentation is Micellar Drug Delivery, a topic which is gaining particular attention in the field of nanomedicine.
0:23
Firstly, I will give you a definition of micelles and then I will introduce the basic physico-chemical aspects, which are essential to understand the mechanism of micelle formation. Afterwards, we'll discuss about the key mechanism of drug encapsulation in this micellar systems, and a brief overview on how micelles can act as a nanocarriers will be provided. Finally, I will show you which tools are typically used in micelles design for drug delivery, and some examples of advanced drug delivery strategies will also be provided.
1:06
According to IUPAC definition, a micelle is a particle of a colloidal dimension that exist in equilibrium with the molecules or ions in solutions from which it is formed. In other words, micelles are formed by self-assembling amphiphilic molecules. This amphiphilic molecules contain hydrophilic polar region, so we call it head and hydrophobic non-polar region, the tail. Micelles are formed in aqueous solution, whereby the polar region phases the outside surface of the micelle and the non-polar region forms the core.