Hello, I'm Francesco Cellesi,
Associate Professor at the Department of Chemistry,
Materials and Chemical Engineering,
"Giulio Natta", Politecnico di Milano in Italy.
The title of this presentation is Micellar Drug Delivery,
a topic which is gaining particular attention in the field of nanomedicine.
Firstly, I will give you a definition of micelles and
then I will introduce the basic physico-chemical aspects,
which are essential to understand the mechanism of micelle formation.
Afterwards, we'll discuss about the key mechanism
of drug encapsulation in this micellar systems,
and a brief overview on how micelles can act as a nanocarriers will be provided.
Finally, I will show you which tools are
typically used in micelles design for drug delivery,
and some examples of advanced drug delivery strategies will also be provided.
According to IUPAC definition,
a micelle is a particle of a colloidal dimension that exist in
equilibrium with the molecules or ions in solutions from which it is formed.
In other words, micelles are formed by self-assembling amphiphilic molecules.
This amphiphilic molecules contain hydrophilic polar region,
so we call it head and hydrophobic non-polar region, the tail.
Micelles are formed in aqueous solution,
whereby the polar region phases the outside surface of
the micelle and the non-polar region forms the core.