Micellar drug delivery

Published on February 27, 2020   33 min

Other Talks in the Series: Drug Delivery

Hello, I'm Francesco Cellesi, Associate Professor at the Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta", Politecnico di Milano in Italy. The title of this presentation is Micellar Drug Delivery, a topic which is gaining particular attention in the field of nanomedicine.
Firstly, I will give you a definition of micelles and then I will introduce the basic physico-chemical aspects, which are essential to understand the mechanism of micelle formation. Afterwards, we'll discuss about the key mechanism of drug encapsulation in this micellar systems, and a brief overview on how micelles can act as a nanocarriers will be provided. Finally, I will show you which tools are typically used in micelles design for drug delivery, and some examples of advanced drug delivery strategies will also be provided.
According to IUPAC definition, a micelle is a particle of a colloidal dimension that exist in equilibrium with the molecules or ions in solutions from which it is formed. In other words, micelles are formed by self-assembling amphiphilic molecules. This amphiphilic molecules contain hydrophilic polar region, so we call it head and hydrophobic non-polar region, the tail. Micelles are formed in aqueous solution, whereby the polar region phases the outside surface of the micelle and the non-polar region forms the core.