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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Introduction/history
- Challenges of drug delivery
- Definitions: what is bioadhesion/mucoadhesion?
- Definitions: administration routes
- What is a MDDS?
- Advantages
- Disadvantages
- Administration routes of mucoadhesion systems
- The anatomical structure of mucosa
- Mucus layer
- Structure of mucin
- Mechanism of mucoadhesion
- Theories of mucoadhesion
- Theories of mucoadhesion: mechanism of bioadhesion
- Factors affecting mucoadhesion
- Ideal characteristics of muco- and bioadhesion systems
- Agents used in MDDSs
- Mucoadhesive agents
- Bioadhesive polymers
- Bioadhesive polymers: natural and semisynthetic
- Bioadhesive polymers: synthetic
- Bioadhesive polymers: water-soluble polymers
- Bioadhesive polymers: water-insoluble polymers
- Bioadhesive polymers according to their charge
- Penetration enhancers
- Examples of penetration enhancers
- Enzyme inhibitors
- Applications of MDDS
- Dosage forms as MDDS
- Dosage forms as MDDS: matrix tablets
- Dosage forms as MDDS: films
- Dosage forms as MDDS: gels and ointments
- Evaluation methods of MDDS
- Advanced MDDS: a paradigm of nanosystems
- Summary
- References
- Thank you
Topics Covered
- Introduction to mucoadhesive drug delivery systems
- History of mucoadhesive systems
- Definition of mucoadhesion
- Theories of mucoadhesion
- Advantages and disadvantages of mucoadhesive systems
- Bioadhesive polymers
- Dosage forms as MDDS
- Advanced mucoadhesive nanosystems
Talk Citation
Siafaka, P.I. (2022, November 30). Mucoadhesive drug delivery systems [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 14, 2024, from https://doi.org/10.69645/SVCN8653.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Panoraia I. Siafaka has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Drug Delivery
Transcript
Please wait while the transcript is being prepared...
0:00
Hello to everyone.
My name is Panoraia Siafaka and
I serve as an
Assistant Professor at
the Faculty of Pharmacy
European University Cyprus
located in Nicosia, Cyprus.
Today, we will be talking about
mucoadhesive drug
delivery systems and
their importance in the
drug delivery field.
0:23
Let me give you now the
outline of this presentation.
First of all, we will
be starting with
the Introduction and history of
mucoadhesive drug
delivery systems.
Later, we will go
through the definition,
theories, and mechanisms
of mucoadhesion.
Furthermore, the
advantages, as well as
disadvantages of
mucoadhesive drug delivery
systems, will be discussed.
Moreover, we will
continue with the role of
bioadhesive polymers
and other materials
using a mucoadhesive
drug delivery system.
In addition, the types of
mucoadhesive drug
delivery systems and
their application will
be also reviewed.
Finally, we will
close the talk with
advanced mucoadhesive
dosage forms
and the summary of
this presentation.
1:12
It is well known that the
mucosal layer acts as a barrier
for the delivery of therapeutics
to reach the target site for
oral, nasal, as well as ocular,
and other local
administration routes.
The clinically available
formulations present
limited effectiveness due to
their poor mucus penetration.
Therefore, the
learning objectives of
this presentation are to
understand the complex
mucus structure,
the terms of bioadhesion
and mucoadhesion,
and overview the different
mucoadhesive drug
delivery systems.
Before we discuss in detail
about mucoadhesive dosage form,
it's time for a little
history lesson.
In the last three decades,
mucoadhesion has gained
an enormous interest
to prolong the residence time of
mucoadhesive formulations
through various mucosal routes
in the drug delivery field;
however, the concept of
mucoadhesion arose more
than 50 years ago.
In 1947, a research team made
various attempts to formulate
a drug delivery system for
the delivery of penicillin to
the oral mucosa using
gum tragacanth and
dental adhesive powders.
Two years later, in 1949
an adhesive penicillin ointment
for topical application,
composed of karaya
gum, and a mixture of
carboxymethylcellulose and
petrolatum was introduced.
In 1959, another formulation
known as Orabase
entered the clinical
practice as a vehicle
for the delivery of drugs
to the oral mucosa.
The formulation comprised
of gelatin, pectin,
and carboxymethylcellulose
can stick on the mouth,
and wet surfaces, and act as
a protective film
over mouth ulcers.
Later years on, in 1968,
a clinical evaluation of
intraoral adhesive
bandages was done,
characterizing them as advanced
oral wound healing systems
due to their
numerous advantages.
Since the early '80s,
the term mucoadhesion has had
considerable attention in
pharmaceutical technology.
When the idea of
mucoadhesion appeared as
a new approach to extending
the residence time of drugs
used on the ocular surface.
At present, various mucoadhesive
drug delivery systems
have been developed for oral,
buccal, nasal, rectal,
and vaginal routes, leading to
both systemic and local effects.