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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Definition of a controlled release product
- Controlled release principles
- Controlled release technologies/systems
- Immediate vs. controlled release drug
- Drawbacks to controlled release drug delivery
- Controlled release physicochemical principles
- Biological factors affecting controlled release
- Formulation approaches
- Diffusion controlled release approach
- Reservoir devices (solid & porous membranes)
- Control of release: reservoir devices
- Reservoir device issues (burst & lag)
- Matrix (monolithic) devices
- Higuchi square root of time model
- Control of release: matrix (monolithic) devices
- Biodegradable systems
- Osmotic systems
- Swellable matrix systems
- Release of drugs from swellable systems
- Applications (examples) of human products
- Geomatrix® technology
- NuvaRing vaginal ring technology
- Implanon contraceptive implant
- NicoDerm QC clear patch
- Bimatoprost ocular ring technology
- Veterinary products using controlled release
- TimeCapsule
- Ivomec SR Bolus
- Captec capsule
- CIDR intravaginal cattle insert
- Books about controlled release principles
Topics Covered
- Definition of a controlled release (CR) product
- Introduction to controlled release drug delivery
- Advantages and disadvantages of formulating a drug into a CR product
- Formulation approaches and mechanisms of drug release
- Applications (examples) of controlled release products in the human field
- Applications (examples) of controlled release products in the veterinary field
Talk Citation
Rathbone, M.J. (2018, November 29). The theory and applications of controlled release principles [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/CCRM3499.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Michael J. Rathbone has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Drug Delivery
Transcript
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0:00
My name is Mike Rathbone.
Today, I'm going to give you an introduction to
the theory and applications of controlled release principles.
This presentation was compiled by myself and Diviya Santhanes.
0:16
This presentation will start with the definition of a controlled release product.
It will then go on to give
an introduction to controlled release drug delivery by looking at
the advantages and disadvantages of formulating a drug into a controlled release product.
Later in the presentation,
the theory of a controlled release product will be over-viewed and some of
the formulation approaches and their mechanisms of release will be examined.
Now, controlled release products can be found in many fields.
Towards the end of this presentation,
we will show you some applications of controlled release products.
This will include controlled release products used
in both the human and veterinary fields.
1:01
A simplified definition for a controlled release product is a dosage form,
which is designed to release a drug at
a predetermined rate for a prolonged period of time.
This process is a deliberate act on the part of the formulator,
through prudent selection of ingredients and/or physical design,
to control the rate of release of the drug from the depths each form,
for periods far longer than immediate release products exhibit.
Controlled release products are available for all routes of
drug delivery and can be developed for human use,
animal use and consumer and diversified uses, including agriculture.