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Printable Handouts
Navigable Slide Index
- Introduction
- Cellular quality control
- Aging and protein homeostasis
- Concept/terminology
- Protein homeostasis
- Proteotoxicity
- What is the role of proteotoxicity in aging?
- Aging increases proteotoxicity
- Aging reduces protein homeostasis
- Deterioration of proteostasis with age
- Concept/terminology: chaperons
- Why are chaperones necessary?
- Protein folding and chaperones in aging?
- Chaperones and aging
- Chaperones in stress and aging: acute stress
- Chaperones in stress and aging: stasis
- Concept/terminology: proteolytic systems
- How do proteolytic systems change with age?
- Proteolytic systems inside the cell
- UPS - proteasome and ubiquitin
- UPS and aging: proteasome
- UPS and aging: ubiquitin
- Proteolytic systems inside the cell: autophagy
- Autophagy and proteostasis
- Types of autophagy in mammals
- Lysosomes and aging
- Aging of the autophagic system
- Macroautophagy and aging - genetic connection
- Autophagy and longevity: genetic connection
- Macroautophagy and aging: caloric restriction
- Does impaired proteostasis affect the organism?
- Proteostasis networks
- Protein homeostasis and translational potential
- Modulators of proteotoxicity?
- Proteostasis networks: next exciting challenges
Topics Covered
- Aging and protein homeostasis
- What is the role of proteotoxicity in aging?
- Role of molecular chaperones in proteoastasis
- Protein degradation systems
- Changes in the ubiquitin/proteasome system with age
- Changes in autophagy with age
- Tele-proteostasis: controlling protein control from the distance
- Proteostasis maintenance as anti-aging intervention
- Pending future questions in the field of proteostasis
Talk Citation
Cuervo, A.M. (2023, June 13). Aging and protein homeostasis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 6, 2024, from https://doi.org/10.69645/GGQQ6776.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ana Maria Cuervo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Autophagy and Lysosomal Storage Diseases
Other Talks in the Series: Aging
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Ana Maria Cuervo,
and I am a professor
at the Albert Einstein
College of Medicine
and Co-Director
of the Aging Center.
I will be talking today
about Protein Homeostasis
and its importance in aging.
0:17
As all of you know,
all proteins in the cells
are continuously exposed
to damaging agents
that can modify
their protein confirmation.
So when a protein is damaged,
it exposes regions
that are going to be particularly
hydrophobic or sticky,
and can abnormally interact
with other proteins
in the cell.
To avoid that,
cells count on systems
that take care
of protein misfolding.
The first ones are chaperones
that if possible
will refold these proteins
to return to their
normal conformation.
And the second system
are the proteases,
where chaperones deliver
the unfolded protein
to undergo degradation.
This is actually
a very conservative system
because when proteins
breakdown into amino acids,
they can be reutilized
to sustain protein synthesis.
So this quality control
mechanisms,
chaperones and proteases
are in place
and functioning in all the cells
when we are young.
However, as we get old
and in particular diseases,
these systems
do not work properly
and result in protein toxicity
or accumulation
of protein damage.
For example, if chaperones
cannot identify,
they unfold the protein
or if the proteolytic systems
are not ready to receive
this unfolded proteins,
they will accumulate
inside the cell
and they will organize
in higher molecular weight
as structures in the form of
protein aggregates
or oligomers
that are toxic for the cell.
So in this lecture,
I will give you some examples
of what is known about chaperone
and proteolytic
systems malfunctioning
during aging
and how can they contribute
to some of the characteristics
of the phenotype of ageing.