I'm Professor Vladimir Anisimov,
I'm a head of department
of Carcinogenesis and Oncogerontology,
Petrov Research Institute
of Oncology in St. Petersburg, Russia.
I will talk today about carcinogenesis
We will talk about historical journey,
age and susceptibility to carcinogens,
cell senescence and cancer,
multi-stage carcinogenesis and aging,
and finally on geroprotectors
On this picture you can see relation
between cancer mortality and age.
It's exponential both in men and women
but it's valid only
for all cancer together.
But nobody knows
what is reason to relation
between aging and cancer.
There are a lot of different opinion,
point of view on this topic.
First of all, Richard Peto write
the paper in 1975,
he wrote, "No relation exists
between aging per se and cancer."
Ten years later,
he published a paper entitled,
"There is no such thing as aging,
and cancer is not related to it."
In '97, he wrote with Richard Doll
in other paper,
again he believed,
"There is no such thing as aging."
John Cairns, in United States,
wrote the paper
where he stressed,
"Aging and cancer
are fundamentally different:
cancer originated as a clone
from a single changed stem cell,
while in aging the whole organism