We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Contents
- Cancer mortality against age in humans
- No relation between aging and cancer
- Aging and cancer are fundamentally different
- Cancrophilia: sum of changes developed in aging
- Carcinogenesis & aging: possibly related
- Age is a leading factor in cancer development
- Cancer and demographic transition
- Inflammaging & age-related diseases
- Age-related increase in cancer incidence
- Correlation between spontaneous tumor incidence
- Age and cancer risk in mouse and human
- Carcinogenic effect of nitroso compounds
- Comparative genetics of longevity and cancer
- Age-related distribution of cancer at different sites
- Mammary gland cancer & age
- Skin cancer & age
- Subcutaneous tissue cancer & age
- Carcinogenic effect of N-nitrosomethylurea
- Risk of cancers & number of cell divisions
- Aging & carcinogen susceptibility: questions
- Old animals: more susceptible to tumor promoters
- Cells from old animals: susceptible to carcinogens
- Effect of age on skin tumor development
- Multistage carcinogenesis: general scheme
- Aging & carcinogenesis: molecular level
- Aging & carcinogenesis: cell/tissue level
- Aging & carcinogenesis: systemic/organism level
- Aging & carcinogenesis: population level
- Aging and multi-stage carcinogenesis
- Multi-stage carcinogenesis and aging: model
- Stem cell: two problematic paths
- Lifespan and tumorigenesis in mutant mice
- Cellular consequences of telomere dysfunction
- Senescent cells: good citizens, bad neighbors
- Senescent cells affect aging-related disorders
- Telomerase reactivation and tissue degeneration
- Сcarcinogenesis in the elderly
- Theory of marginotomy: telomere and telomerase
- Age-related telomere shortening in human
- Age-related telomere shortening in lymphocytes
- Effect of age on the lung metastases
- Tumor incidence in young and old rats (hepatoma)
- Conclusions so far
- Levels of cancer cells in the body: consequences
- Growth rate of tumors in young and old
- 5- Bromodeoxyuridine (BrdURd)
- BrdURd induces carcinogenesis & its modification
- Persistent effect (neonatally administered BrdUrd)
- Mammary carcinomas: BrdU & Estradiol
- Aging and carcinogenesis: initiation & promotion
- Main groups of geroprotectors
- Higher mortality rate in obese persons
- Calorie restricted diet
- Effects of hyperinsulinemia
- NIA primate project: main results
- Calorie restriction and atherosclerosis in humans
- Calorie consumption & life expectancy (humans)
- Conclusion about calorie restriction
- TOR as a target for pharmacological intervention
- Phenformin effect on lifespan & tumorigenesis
- 1-butylbiguanide: lifespan & tumorigenesis
- Effect of buformin on spontaneous tumorigenesis
- Metformin: lower carcinogenesis, higher survival
- Metformin increases mean lifespan (young mice)
- Metformin inhibits tumorigenesis (old mice)
- Effect of metformin on estrous function in mice
- Metformin improves healthspan, not tumor rate
- Phenformin & carcinogenesis in rats (NMU)
- Phenformin & carcinogenesis in rats (X-ray)
- Phenformin inhibits colon carcinogenesis in rats
- Metformin effects on colon carcinogenesis
- Metformin effects on cervicovaginal tumors
- Metformin prevents carcinogenesis in rodents
- Metformin and cancer prevention in human
- Metformin effect on cancer rate in diabetics
- Diabetes and expected lifespan
- Higher survival in type 2 diabetics given metformin
- Metformin & cancer
- Metformin as a geroprotector
- TAME: Targeting Aging with Metformin
- Stem cell paths: calorie restriction
- Types of aging delay and cancer: mice and rats
- Survival curve patterns in Sweden (1861-1999)
- Cancer morbidity & mortality in USA (1973-1997)
- Types of aging delay and cancer: humans
- From longer lifespan to longer healthspan
- Geroscience should also target the young
- Final message
Topics Covered
- Historical journey into carcinogenesis and aging
- Age and susceptibility to carcinogens
- Cell senescence and cancer
- Multi-stage carcinogenesis and aging
- Geroprotectos and cancer
Talk Citation
Anisimov, V.N. (2017, April 30). Carcinogenesis and aging [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/LXJV8359.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Vladimir N. Anisimov has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Aging
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, everybody,
I'm Professor Vladimir Anisimov,
I'm a head of department
of Carcinogenesis and Oncogerontology,
Petrov Research Institute
of Oncology in St. Petersburg, Russia.
I will talk today about carcinogenesis
and aging.
0:17
We will talk about historical journey,
age and susceptibility to carcinogens,
cell senescence and cancer,
multi-stage carcinogenesis and aging,
and finally on geroprotectors
and cancer.
0:32
On this picture you can see relation
between cancer mortality and age.
It's exponential both in men and women
but it's valid only
for all cancer together.
But nobody knows
what is reason to relation
between aging and cancer.
There are a lot of different opinion,
point of view on this topic.
0:59
First of all, Richard Peto write
the paper in 1975,
he wrote, "No relation exists
between aging per se and cancer."
Ten years later,
he published a paper entitled,
"There is no such thing as aging,
and cancer is not related to it."
In '97, he wrote with Richard Doll
in other paper,
again he believed,
"There is no such thing as aging."
1:27
John Cairns, in United States,
wrote the paper
where he stressed,
"Aging and cancer
are fundamentally different:
cancer originated as a clone
from a single changed stem cell,
while in aging the whole organism
gets older."