Carcinogenesis and aging

Published on April 30, 2017   40 min

Other Talks in the Series: Aging

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Hello, everybody, I'm Professor Vladimir Anisimov, I'm a head of department of Carcinogenesis and Oncogerontology, Petrov Research Institute of Oncology in St. Petersburg, Russia. I will talk today about carcinogenesis and aging.
We will talk about historical journey, age and susceptibility to carcinogens, cell senescence and cancer, multi-stage carcinogenesis and aging, and finally on geroprotectors and cancer.
On this picture you can see relation between cancer mortality and age. It's exponential both in men and women but it's valid only for all cancer together. But nobody knows what is reason to relation between aging and cancer. There are a lot of different opinion, point of view on this topic.
First of all, Richard Peto write the paper in 1975, he wrote, "No relation exists between aging per se and cancer." Ten years later, he published a paper entitled, "There is no such thing as aging, and cancer is not related to it." In '97, he wrote with Richard Doll in other paper, again he believed, "There is no such thing as aging."
John Cairns, in United States, wrote the paper where he stressed, "Aging and cancer are fundamentally different: cancer originated as a clone from a single changed stem cell, while in aging the whole organism gets older."