My name is Jan Vijg,
I'm from the Department of Genetics,
Albert Einstein College of Medicine in New York.
And this lecture will be about DNA damage and aging.
So for quite a while, we learned about aging essentially through longevity.
We now know a lot of genes and also even chemical compounds that in
some way control longevity in invertebrate organisms but in fact also in mice.
And maybe there's even an effect in humans,
there's some evidence for that.
But in spite of that information that we know,
we're able to collect about what controls longevity.
We know still very little about the process that limits longevity and that's aging.
And what you basically see in this slide it's sort of a black box.
That's of course, a lot of suspicions about causes of aging,
we know very little about it.
One major hypothesis about what causes aging is the idea that
aging is caused by DNA damage in some way or the other.