Cardiac aging

Published on May 31, 2016   36 min

Other Talks in the Series: Aging

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Hello. My name is Ying Ann Chiao. and I'm Peter Rabinovitch. We'll be presenting on the topic cardiac aging.
Cardiovascular diseases are the leading cause of death for the elderly population. In this lecture, we will discuss the impact of aging on the heart. We'll begin by an overview of cardiac aging in human and mammalian models. We'll then discuss the involvements of multiple molecular mechanisms in the pathogenesis of cardiac aging and the recent advances in the development of interventions to delay or treat cardiac aging as well as perspectives on the future of the cardiac aging field.
Multiple factors have been shown to increase the risk of cardiovascular disease. The Heart, Lung, and Blood Institute of National Institutes of Health has listed risk factors for cardiovascular disease, including high blood cholesterol and triglyceride, high blood pressure, diabetes, overweight, smoking, lack of physical activity, unhealthy diet, and stress. The Center for Disease Control and Prevention also lists blood cholesterol, hypertension, diabetes, and family history as risk factors. Most of the research assays on prevention of cardiovascular diseases have focused on the development of interventions that target these traditional cardiovascular risk factors but have ignored a major risk factor for cardiovascular diseases aging.
This slide shows the prevalence of cardiovascular disease in adults 20 years or older of age by age and sex from the national health and nutrition examination survey 2009 to 2012 from heart disease and stroke statistic. This data includes coronary heart disease, heart failure, stroke, and hypertension. As you can see, the patterns of cardiovascular diseases increase with age dramatically. The prevalence of cardiovascular disease is close to 70% for Americans 60 to 70 years of age and is over 80% for Americans over 80 years of age. In addition to the increased prevalence of cardiovascular diseases, aging also leads to deterioration of the structure and function of the heart in individuals without overt cardiovascular disease.