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Printable Handouts
Navigable Slide Index
- Introduction
- Talk overview
- The study of ageing
- Ageing is an unsolved problem
- Key biogerontology questions (1)
- Microarrays
- Molecular signature of ageing
- Transcriptome sequencing
- RNA-seq of ageing tissues
- RNA-seq of calorie restriction
- Proteomics
- Epigenetic changes with age
- Other large-scale approaches
- Challenges in data analysis
- Approaches for analysis
- Functional enrichment
- Adaptive responses to ageing
- Key biogerontology questions (2)
- Ageing process is plastic
- Human ageing genomic resources
- GenAge build 20
- The genome as the digital code of life
- Genetic determinants of human longevity (1)
- Genetic determinants of human longevity (2)
- DNA sequencing for everyone
- First long-lived biomedical model
- The naked mole-rat genome resource
- Sequencing the bowhead whale genome
- Genome assembly
- Finding candidate bowhead whale genes
- Promising bowhead gene candidates
- The bowhead whale genome resource
Topics Covered
- Key biogerontology questions
- Molecular signature of ageing
- Transcriptome sequencing
- RNA-seq of ageing tissues and calorie restriction
- Microarrays & Proteomics
- Epigenetic changes with age
- Other large-scale approaches
- Approaches & challenges for data analysis
- Functional enrichment
- Adaptive responses to ageing
- Plasticity of the ageing process
- Human ageing genomic resources
- GenAge database
- The genome as the digital code of life
- Genetic determinants of human longevity
- The naked mole-rat genome resource
- Sequencing the bowhead whale genome
Talk Citation
Magalhães, J.P.D. (2017, March 29). Omics approaches and large-scale data analysis in ageing research 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/EOND5702.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. João Pedro de Magalhães has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Omics approaches and large-scale data analysis in ageing research 1
Published on March 29, 2017
38 min
Other Talks in the Series: Aging
Transcript
Please wait while the transcript is being prepared...
0:00
My name is
João Pedro de Magalhães.
And I'm a Senior Lecturer
at University of Liverpool,
where I lead Integrative Genomics
of Ageing Group.
And our research focuses
on understanding
the genetic cellular, molecular
mechanisms of aging,
in particular,
using high-throughput approaches.
And this lecture will focus
on different omics approaches
and large-scale data analysis,
and how these have been applied
in aging research.
0:25
So after a brief introduction,
I'll discuss several technical
and methodological platforms
that are available to study aging
from different perspectives,
and then I'll also discuss
data analysis, data integration,
and network biology approaches,
or how to make sense
of all the data
that's being generated.
0:45
And I'll start by telling you
the story of Qin Shi Huang.
He was the first emperor
of the Qin dynasty in China
over 2,000 years ago.
He was a very wealthy
and powerful man.
He ordered construction
of the Terracotta Army
to protect his mausoleum.
But he didn't want
to grow old and die
and so he ordered
the court physicians at that time
to discover or develop
an elixir of youth.
And they came up
with these small pills
that he was to take every day
that would allow him
to live forever,
or so they claimed.
Now unfortunately for him,
the key ingredient of those pills
was mercury,
which we now know is toxic.
And so sadly and ironically,
he died of mercury poisoning.
Now the reason I tell the story is,
first of all, it shows that
from the beginning of time,
we've wanted to avert
age-related degeneration
and extend our lives,
but also, and most importantly,
it shows that
what we can achieve in a given time
depends on
our current technological progress.
If I wanted to build an iPhone
50 years ago,
I could put all the money
in the world into it,
I would not have been able to do it
in a timely fashion.
And what I hope
to convince you today
is that there are a huge amount
of very exciting
and very powerful technologies
that we can use to study aging,
that I believe will allow us
to gain insight
into the aging process
in a way that's never
been possible before.