Life course of the brain during normal aging and Alzheimer's disease

Published on May 31, 2016   36 min

Other Talks in the Series: Aging

0:00
I'm Caleb Finch. I'm a Neurobiologist, PhD at the University of Southern California. My talk will be on the life course of the brain during normal aging and Alzheimer's disease. And I hope to bring to your attention changes that begin relatively early and are benign, as they are understood and may progress in some individuals to the devastating endpoints of Alzheimer's disease.
0:28
The next slide shows truly remarkable woman, unique in her lifespan of 122 years and unique also in reaching that advanced age with a few, if any signs of mental deterioration. This is Jeanne Calment and there is no one who has approached her lifespan since. The sad fact is that about 50% of centenarians are mentally impaired.
0:59
The next slide shows the devastating reality that after the age of 60, in all human populations, the risk of Alzheimer's increases exponentially. The risk doubles every five years after the age of 60 and that curve has a horrible prediction that if you live long enough, you'll get Alzheimer's. This is obviously not the case, for some individuals seem to be protected. We want to understand that.
Hide

Life course of the brain during normal aging and Alzheimer's disease

Embed in course/own notes