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Printable Handouts
Navigable Slide Index
- Introduction
- Age-related vs. infectious diseases
- Targeting pathology: tricky
- What is ‘aging’, exactly?
- Biological aging in three words
- Misstep 1: treating aging like infections
- Diseases and aging: popular view
- Diseases and aging: correct view
- Misstep 2: treating technology like science
- Targeting metabolism: also tricky
- Misstep 3: over simplistic extrapolation
- Inconvenient truths about famine
- Rejuvenation biotech: the fourth paradigm
- Comparison: car maintenance
- Why is rejuvenation biotech so promising?
- Addressing each category
- Damage repair approaches
- Taxonomy validation
- Focusing on one category
- Intracellular junk in the artery
- An enzyme protects cells from 7KC
- The hallmarks of aging
- Interventions that might extend human life span
- Concluding remarks
Topics Covered
- Overview of previous views of treating aging
- Aging related damage taxonomy breakdown
- Aging maintenance breaking technologies overview
- Future interventions that might extend human life span
Talk Citation
de Grey, A. (2017, September 28). Rejuvenation biotechnology: postponing ill-health via comprehensive damage repair [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2024, from https://doi.org/10.69645/MGMC1437.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Aubrey de Grey has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Aging
Transcript
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0:00
In this concluding lecture of the series,
I shall try to draw us together many of the strands of research
and thinking that have been discussed by my colleagues in previous lectures.
And I shall try to give you my own impression of what this means for the prospects
for intervention in human aging in
the foreseeable future and postponement of the ill health,
that of course is currently associated with old age.
0:34
I'm going to start right at the top.
I'm going to ask the question which not enough people in society really ask,
and at least not with the determination to come up with an answer that's useful.
The question is simply,
why have we been so much less successful in
developing medicines to alleviate and address the ill health
of old age than we have with respect to
the diseases that used to be so prevalent early in life,
in particular most infectious diseases?
Of course, we know that a couple of hundred years ago,
at least one third of babies would die before the age of one,
and of course there was huge amount of mortality in childbirth and throughout early life.
This has been virtually eliminated in the industrialized world,
and it is becoming rapidly rarer even in the developing world as a result of
really pretty elementary medical interventions as
compared to the kinds that are being developed these days.
And yet, even the kinds of medical interventions that are being developed
these days are only having very limited success against the ill health of old age.
We really must ask ourselves seriously why that is.
And I believe that that is the starting point for
any discussion of how this might be better.
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