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Topics Covered
- The two SARS-CoV-2 proteases found and their mechanisms of action
- Designing inhibitors to these proteases
- Steps taken in this research
- Future work
Biography
Prof. Dr. Müller: Christa E. Müller is a Full Professor of Pharmaceutical/Medicinal Chemistry at the Rheinische Friedrich Wilhelms-University Bonn in Germany and Director of the PharmaCenter Bonn.
She completed her PhD studies at the University of Tübingen, Germany, in Pharmaceutical/Medicinal Chemistry in 1988 followed by a postdoctoral stay at the NIH (Bethesda, MD, USA). After her return to Tübingen she completed her habilitation and became Associate Professor of Pharmaceutical Chemistry at the University of Würzburg, Germany, in 1994. Since 1998 she holds a Full Professorship at the University of Bonn, Germany. From 2001-2004 and from 2010-2015 she served as Vice-Rector of Bonn University.
Professor Müller is Vice-President for Research of the German Pharmaceutical Society (DPhG) since 2019, and President of the German Purine Club since 2015. She was recently appointed Editor-in-Chief of ACS Pharmacology & Translational Science, and serves as a member of several Scientific and Editorial Boards of other scientific journals. She has published more than 450 scientific papers and patents. Among a number of prizes, she received the Nauta Award for Medicinal Chemistry and Chemical Biology by the European Federation of Medicinal Chemistry (EFMC) in 2018, and the Tony Holy Lecture Award in Prague (Czech Republic) in 2019.
Her main interests are focused on medicinal chemistry and pharmacology of purine binding membrane proteins (receptors and enzymes), orphan GPCRs, and G proteins, and recently on the development of drugs for the treatment of COVID-19 and other coronavirus infections.
Prof. Dr. Gütschow: Michael Gütschow studied Biochemistry at the University of Leipzig, Germany. He received his PhD in pharmaceutical Chemistry in 1987 under the supervision of Prof. Günther Wagner. Until 1993, he was working as Scientific Assistant at the Department of Biosciences at the University of Leipzig. In 1993, he became a Postdoc at the Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, for one year with Prof. James C. Powers. In 1998 he received his Habilitation at the University of Leipzig, Pharmaceutical Institute, in the field of Pharmaceutical Chemistry. He held several short visiting fellowships, for example at the Friedrich-Miescher-Institute Basel, and Novartis Basel, Switzerland. Since 2001 he is Professor for Pharmaceutical Chemistry at the University of Bonn. He holds the position of head of the Department of Pharmacy and was Director of the Pharmaceutical Institute. His research interests includes the design of inhibitors and activity-based probes for cysteine and serine proteases, development of PROTACs, synthesis of bioactive heterocycles, peptidic and peptidomimetic drugs, and the biochemistry of enzyme-drug interactions. He published more than 270 papers to the scientific topics mentioned.
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Talk Citation
Müller, C.E. and Gütschow, M. (2021, April 22). Identifying SARS-CoV-2 proteases [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/FXBW2188.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dr. Christa E. Müller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Dr. Michael Gütschow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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