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Topics Covered
- Update on the immune response to SARS-CoV-2
- Current knowledge on the stability of the immune response
- The role of interferon alpha in the response
- The new virus strain in the UK (VUI – 202012/01)
- Research looking into the long-term health issues arising from COVID-19
Biography
Paul Klenerman trained in medicine at Cambridge and Oxford and specialised in infectious diseases. He did his PhD in viral immunology at Oxford University and a postdoc in Zurich before returning to Oxford to establish a lab looking at immune responses to infection. The work includes studies of hepatitis C and a range of viruses affecting the lungs and liver - looking at how these evade the immune response, and the development of vaccines. He is focused especially on novel T cell responses in the mucosal surfaces which are critical for early host defence. He is an NIHR senior fellow and a Wellcome Trust investigator and holds a chair in the Nuffield Department of Medicine in Oxford.
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Talk Citation
Klenerman, P. (2020, December 22). The immune system response to the SARS-CoV-2 virus: December 2020 update [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 2, 2023, from https://hstalks.com/bs/4498/.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Audio Interview
The immune system response to the SARS-CoV-2 virus: December 2020 update
Published on December 22, 2020
18 min
Other Talks in the Playlist: Interviews on Covid-19
Transcript
Please wait while the transcript is being prepared...
0:00
Interview: Professor Klenerman, thank you for doing this update with us today on
the immune system response to the SARS-CoV-2 virus,
your last interview with us on this topic being in July this year.
What are some of the main changes in the understanding of the mechanisms
of how the immune system responds to SARS-CoV-2?
Prof. Klenerman: I think the principles were established reasonably early about the major responses.
I guess in the last few months
there haven't been huge surprises,
but quite a lot of refinement about these responses.
Much more is known about the stability of the responses as
well because we've just had more time to study them, and
of course, many more patients have been studied now.
I think the main messages are still that there's a blunted early innate response,
but later on, in people who are very sick,
the innate response takes over in a very dysregulated way.
Some of the papers have used that word
'dysregulation', it's a coordination of the immune response
later in the disease and seems to be a problem in the people who are sickest, and
there's a bit of debate over whether it's best described as a 'cytokine storm'.
But it's an OK description of something which is quite chaotic,
I think that's probably the point to get across, and that's not unique to COVID
but it is quite striking in these patients.
In some of the white blood cell subsets that are triggered by those cytokines
(the neutrophils, and the myeloid set of cells and monocytes),
there are some quite striking changes.
Then with the lymphocytes, which are more responsive for adaptive immunity,
we know a good deal more about the quality of the neutralizing antibodies,
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