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Topics Covered
- SARS-COV-2 compared with other coronavirus strains
- How this comparison can help in containment, treatment, and vaccination
- Future considerations for vaccine development
- Other possible treatments for COVID-19
Biography
Dr. Perlman received his Ph.D. in Biophysics from M.I.T., Cambridge, Massachusetts and his M.D. from the University of Miami, Miami, Florida. He was trained in Pediatrics and Pediatric Infectious Diseases at Boston Children’s Hospital, Boston, Massachusetts. His current research efforts are focused on coronavirus pathogenesis, including virus-induced demyelination and the Severe Acute Respiratory Syndrome (SARS), the Middle East Respiratory Syndrome (MERS), and COVID-19.
His laboratory has developed several novel animal models useful for studying pathogenesis and evaluating vaccines and anti-viral therapies. His studies are directed at understanding why aged patients and mice developed more severe disease than younger individuals after infection with SARS-CoV or SARS-CoV-2 and also on why there is a male predominance in patients with more severe disease after infection with SARS-CoV, MERS-CoV or SARS-CoV-2. He and his colleagues demonstrated that transduction of mice with an adenovirus expressing the human receptor for MERS-CoV, DPP4, rendered them sensitive to infection, providing the first rodent model useful for studying MERS. Similar approaches have been used to develop a mouse model for COVID-19.
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Talk Citation
Perlman, S. (2020, April 5). SARS-CoV-2: What we need to know and possible future therapies [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/DHGE8670.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stanley Perlman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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Transcript
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