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We hope you have enjoyed this free, full length talk
Topics Covered
- Mortality rates of SARS-CoV-2 and known risk factors
- Provenance of SARS-CoV-2 and related viruses
- SARS-CoV-2 as compared with seasonal influenza
- Potential impact of future mutations
- Prospective therapies
Biography
Ralph Baric is Professor of Microbiology and Immunology at the School of Medicine and Professor of Epidemiology at Gillings School of Global Public Health at the University of North Carolina, Chapel Hill. Dr. Baric’s research specializes in coronaviruses and emerging infections such as Zika virus. Most of the research in the Baric Lab uses coronaviruses as models to study the genetics of RNA virus transcription, replication, persistence and cross-species transmission. In 2017, Dr. Baric was included in the Clarivate Analytics’ Highly Cited Researchers list, which recognizes researchers from around the world who publish the most widely cited papers in their field.
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Talk Citation
Baric, R. (2020, March 11). The COVID-19 outbreak: an update on the SARS-CoV-2 virus [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 6, 2023, from https://hstalks.com/bs/4208/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ralph Baric has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Audio Interview
The COVID-19 outbreak: an update on the SARS-CoV-2 virus
Published on March 11, 2020
12 min
Other Talks in the Series: Interviews on Covid-19
Transcript
0:00
Interviewer: Professor Baric,
thank you very much for taking the time to
do this interview with us on the topic of
the worldwide ongoing SARS-CoV-2
outbreak and the disease it triggers
called COVID-19. Let me start by asking you
a few questions regarding the context of
this virus and its outbreak.
Recent estimates show this current
SARS-CoV-2 has a mortality rate reaching
above 3%. How accurate is this in your
opinion, and how does this compare with
the severity of the Spanish flu of 1918?
Prof. Baric: Let me start off by saying that the
Spanish flu mortality rate was estimated
somewhere between 2.5 and 3.5%. The current
estimates for the SARS-2 outbreak strain
is about 3.4% based on 100,000
defined cases, positive cases.
Of course, the big question is what is the
actual denominator and are we capturing
all those cases.
Most people, most scientists, most
epidemiologists would argue, we probably
are not capturing most of the cases, so
the actual mortality rate is probably
a half or one quarter of what is being
reported from the known cases, mostly
because we're not detecting all the
infected cases globally.
Now, an important caveat here is that
SARS-2 causes an age-related mortality.
Consequently, if you're over the age of
80, then the mortality rate is about 15%.
If you're
between 60 and 70, for example,
the mortality rate is around 3.4%.
If you're below the age of 40, the
mortality rate is less than 0.4%.