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Topics Covered
- Rationale and approach to investigating ACE2 and integrin SLiMs
- Update on the mechanism of ACE2- and integrin-mediated viral entry into cells
- SLiMs and their essential role in cellular endocytosis
- Possibility of targeting specific SLiMs as a novel antiviral therapy
- Efficacy of Chloroquine and Chlorpromazine as potential small-molecule therapeutics against viral entry into cells
- The power of interfering with integrin-dependent cellular endocytosis as a proactive defense against coronaviruses
Biography
Toby Gibson is at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. He studied Molecular Biology at Edinburgh University and did his PhD at the LMB, Cambridge, sequencing EBV. He is a computational biologist: i.e. a biologist who finds computers to be useful adjuncts to biological research. He is a co-developer of the widely used Clustal series of multiple sequence alignment software. He oversees the development of ELM, the Eukaryotic Linear Motif resource (http://elm.eu.org/) devoted to protein sequence motifs involved in cell signalling and regulation. Toby is fascinated by the structure-function paradigm for massively interacting hub proteins such as p53, IRS-1, AKAPs and many, many more. These are characterised by large natively unstructured protein segments that are repositories of abundant “linear motifs” or SLiMs - short regulatory sites that interact with other proteins. During the Pandemic, Toby has been working with colleagues on SLiMs in the SARS-CoV-2 entry system.
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Talk Citation
Gibson, T. (2021, March 20). The role of short linear motifs (SLiMs) in SARS-CoV-2 entry into human cells [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/XUBN4002.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Toby Gibson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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