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Nanocrystals in drug delivery

Published on July 31, 2024   27 min

Other Talks in the Series: Drug Delivery

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0:00
Hello. My name is Eliana Souto, and I was offered to talk about the topic of nanocrystals in drug delivery.
0:10
I would like to start by saying that the process we have been witnessing in techniques that currently support drug discovery, as happens with genomics, proteomics, and high-throughput screening methods, among others, is resulting in an exponential increase in the number of potential candidates to be used as active pharmaceutical ingredients. In rigor, a new drug candidate, undergoes a time-consuming development process, and we still face a shortage of examples of these potential drugs actually reaching Phase 1 clinical studies. Within this scenario, formulation development becomes instrumental to ensure that a potential drug candidate is bioavailable and reaches the site of action.
0:57
Besides that, as a number of physical and chemical properties of drugs are becoming even more diversified, and improved, with smart drug delivery systems with functional properties are being proposed. Most of the problems encountered in formulation development are attributed to: the low water solubility of potential drug candidates; the low in vitro and in vivo stability; the reduced bioavailability as a result of the limited absorption of the tract; the risk of systemic distribution requiring targeted delivery; difficulties in being approved by the regulatory authorities, and also the difficulties in scaling up of the production process.