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Printable Handouts
Navigable Slide Index
- Introduction
- Porous drug carriers
- Mesoporous drug carriers
- Inorganic nanoparticles: imaging/diagnostics
- Organic nanoparticles: drug delivery
- Design strategies for drug delivery systems
- Nanopharmaceuticals
- Poorly soluble drugs
- Biopharmaceutics classification system
- Mesoporous drug carriers
- Silicon dioxide (SiO2)
- Silica nanoparticles: flexible design
- Controllable size, shape, structure
- Mesoporous silica nanoparticles (MSNs): flexible designs
- Silica NPs via the sol-gel approach
- Mesoporous silica (SiO2) materials
- MSNs as drug delivery carriers
- Nanopharmaceuticals: nanocarrier + drug(s)
- Spatial control: active cellular targeting (the “magic bullet” concept)
- Targeted delivery in vitro
- Targeted delivery in vivo
- Critical parameters in the design of MSNs for anti-cancer therapy
- Temporal control: therapeutic delivery (drug release)
- Nobel Prize in Chemistry 2016: molecular machines
- Temporal control: triggered release
- Intracellular trafficking of carrier vs. cargo
- Gene delivery + drug combination therapy
- Nanocarriers and biomolecules
- MSN designs for imaging/diagnostics
- Loaded fluorophores: in vivo imaging
- Formulation of MSNs and personalized drug products
- 2D/3D printing of MSNs
- Conclusions: flexible design options
- Control on all levels and collaborative efforts
- Additional reading
- Thank you
Topics Covered
- Drug delivery systems
- Advantages and characteristics of porous materials
- Mesoporous silica nanoparticles (MSNs)
- Material design aspects for drug delivery efficacy
- Formulation aspects to be considered
- Examples of in vitro cellular targeting
- In vivo therapeutic delivery and detection
Talk Citation
Rosenholm, J. (2020, October 29). Inorganic porous drug delivery carriers [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/NMRH3068.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jessica Rosenholm has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Drug Delivery
Transcript
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0:00
Welcome to this talk on inorganic porous drug delivery carriers.
My name, Jessica Rosenholm.
I am a professor in Pharmaceutical Development at
the Pharmaceutical Sciences Laboratory at Abo Akademi University in, Turku, Finland.
In this talk, I will be telling you something about how inorganic porous materials,
perhaps mainly nanomaterials, can be utilized in different biomedical applications.
0:33
Porous drug carriers and porous materials have to
date found a range of different applications in drug delivery,
perhaps mainly in the front controlled release applications due to debt.
If you can tune the porous structure,
you can also usually tune the drug release kinetics out from the material.
When you then can produce these materials in different morphologies such as,
for instance, films or implants,
needles and so on,
you can also make a range of different materials useful
for eluding drugs at different kinetics in different applications.
Because you pack the active ingredients into the porous matrix,
the material itself can also quite efficiently protect these kind
of fragile active pharmaceutical ingredients from the environment.
So this is also another advantage of the porous materials,
as we shall see later in this talk.
One quite big application of these in drug delivery that should
be mentioned is the improvement of the solubility or poorly soluble drugs,
which is something you can achieve by packing
active pharmaceutical ingredients into porous material.
So this we will have a bit closer look at also.