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0:00
Hello.
My name is Ying Ann Chiao.
and
I'm Peter Rabinovitch.
We'll be presenting
on the topic cardiac aging.
0:09
Cardiovascular diseases are
the leading cause of death
for the elderly population.
In this lecture, we will discuss
the impact of aging on the heart.
We'll begin by an
overview of cardiac aging
in human and mammalian models.
We'll then discuss the involvements
of multiple molecular mechanisms
in the pathogenesis of cardiac
aging and the recent advances
in the development of
interventions to delay or treat
cardiac aging as well as
perspectives on the future
of the cardiac aging field.
0:41
Multiple factors have
been shown to increase
the risk of cardiovascular disease.
The Heart, Lung, and Blood Institute
of National Institutes of Health
has listed risk factors
for cardiovascular disease,
including high blood cholesterol and
triglyceride, high blood pressure,
diabetes, overweight, smoking,
lack of physical activity,
unhealthy diet, and stress.
The Center for Disease
Control and Prevention
also lists blood cholesterol,
hypertension, diabetes,
and family history as risk factors.
Most of the research
assays on prevention
of cardiovascular diseases
have focused on the development
of interventions that target these
traditional cardiovascular risk
factors but have
ignored a major risk
factor for cardiovascular
diseases aging.
1:34
This slide shows the prevalence of
cardiovascular disease in adults 20
years or older of age by age
and sex from the national health
and nutrition examination
survey 2009 to 2012
from heart disease
and stroke statistic.
This data includes coronary
heart disease, heart
failure, stroke, and hypertension.
As you can see, the patterns
of cardiovascular diseases
increase with age dramatically.
The prevalence of
cardiovascular disease
is close to 70% for Americans
60 to 70 years of age
and is over 80% for Americans
over 80 years of age.
In addition to the
increased prevalence
of cardiovascular
diseases, aging also
leads to deterioration
of the structure
and function of the heart
in individuals without overt
cardiovascular disease.
