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Printable Handouts
Navigable Slide Index
- Introduction
- Learning objectives
- The need for targeted drug delivery systems
- What are liposomes and what are their advantages?
- What are liposomes?
- Why are liposomes preferred?
- Examples of liposomal drug delivery systems in the market
- Types of liposomal drug delivery systems
- Conventional liposomes
- Steric-stabilized liposomal drug delivery systems (1)
- Steric-stabilized liposomal drug delivery systems (2)
- Ligand-targeted liposomal drug delivery systems
- Combination: the newer generation of liposomal drug delivery system
- Summary of liposomal drug delivery system types
- Combination: the newer generation of liposomal drug delivery system
- The reticuloendothelial system and clearance
- Opsonin and vesicle destabilization
- Enhanced permeability and retention effect (EPR)
- Accelerated blood clearance effect (ABC)
- Complement activation-related pseudo allergy (CAPRA)
- Solutions to CARPA
- Thank you
Topics Covered
- Types of liposomes
- Advantages of liposomes for drug delivery
- Doxil
- DaunoXome
- Sterically-stabilized liposomes
- Ligand-targeted liposomes
- Polyethylene glycol (PEG)
- Challenges with liposomes
Talk Citation
Deen, G.R., Hasan, B. and AlAnsari, R. (2023, September 28). Liposomes as a drug delivery system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/ZNRZ2514.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. G. Roshan Deen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Ms. Bushra Hasan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Ms. Renad AlAnsari has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Liposomes as a drug delivery system
Published on September 28, 2023
17 min
Other Talks in the Series: Drug Delivery
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Renad AlAnsari from
the School of Medicine at
the Royal College of
Surgeons in Ireland,
Medical University of Bahrain.
My colleague, Bushra and
I are attached to
the Materials for
Medicine Research Group
led by Dr. Roshan Deen.
The main research focus of
our group is the development
of new materials like stimuli
responsive hydrogels,
nanocomposites, and
green nanoparticles for
biomedical applications.
In this lecture, we will
be talking about the use
of liposomes as drug
delivery systems.
I'll be presenting the first
section of this lecture,
and Bushra will be presenting
the second section.
0:38
By the end of this lecture,
you should be able
define liposomes
and list their advantages.
Recall examples of liposomal
drug delivery systems
in the market and what
they're used for.
List the different types of
liposomal drug delivery systems
and explain how
each one functions.
Finally, list and
understand the challenges
to using liposomes as
drug delivery systems.
1:03
Now we're going to talk
about the need for
targeted drug delivery systems.
In the treatment of disease
the drug or the therapeutic
agent needs to be
available at the target site
and at the right concentration.
If the pharmacokinetics is poor,
the bioavailability of
the drug is limited and
could lead to toxicity
of tissues at off sites.
Now this is where the importance
of nanotechnology
and nanomedicine
is fully recognized in
the development of targeted
drug delivery systems.
Nanotechnology plays
a very important role in
translational research,
particularly in the
field of medicine.
Using this technology,
the disease can be
diagnosed and treated
at the clinical level.
Nanoparticles and
liposomes are widely
used in the development of
targeted drug delivery and
gene delivery systems
for the delivery of
various drugs and genes to
the target sites
in the human body.