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- Prof. Alberto Mantovani
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- Prof. Alberto Mantovani
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Printable Handouts
Navigable Slide Index
- Introduction
- Pentraxins
- The prototypic long pentraxin ptx3
- The pentraxin superfamily (1)
- C reactive protein
- The pentraxin superfamily (2)
- PTX3 production regulation in myelomonocytic cells
- The yin-yang of macrophage polarization
- Localization of PTX3 in human neutrophil granules
- Localization of PTX3 in NETs
- Neutrophil nuclei morphology
- Neutrophil extracellular traps
- Cellular and humoral innate immunity
- Crystal structure of SAP–FcɣRIIa complex
- Recruitment of CD11b and CD32 by PTX3
- Mechanism of action for PTX3 opsonizing activity
- PTX3 binds P-selectin
- PTX3 mediated regulation of leukocyte recruitment
- Ligands recognized by PTX3
- Inhibition of complement activation pathways
- PTX3 interacts with complement
- PTX3 structure and function
- PTX3 actions
- Susceptibility of PTX3 -/- mice to pyelonephritis
- PTX3 in innate immune response against UPEC
- PTX3 translation
- PTX3 translation: Genetics
- PTX3 polymorphysm & infection
- PTX3 in mice with invasive aspergillosis
- PTX3 increases the effect of L-AMB and D-AMB
- PTX3 in rat with invasive aspergillosis
- Inflammation and cancer
- Monocyte - macrophage lineage cells
- TAMs in tumor progression
- Increased PTX3 -/- susceptibility to carcinogenesis
- PTX3 deficiency & increased inflammation
- Which are the mechanisms?
- PTX3 deficiency & complement activation
- Role of C3 and interaction with Factor H
- CCL2 in promoting cancer-related inflammation
- PTX3-deficiency, gene instability & DDR
- Methylation of the PTX3 gene in human cancer
- PTX3 as an onco-suppressor in mouse and human
- Two pathways link inflammation and cancer
- Altered skin wound healing in PTX3 deficient mice
- Altered lung repair in PTX3-deficient mice
- Relevance of PTX3 fibrin & plasminogen interaction
- PTX3 in tissue repair
- Acidification sets PTX3 in a tissue repair mode
- Matrix and microbe recognition
- PTX3, a soluble pattern recognition receptor
- Overview of humeral innate immunity
- PTX3 as an ancestor of antibodies (ante-antibody)
Topics Covered
- The pentraxin superfamily
- The PTX3 pentraxin function in innate immunity and inflammation
- Macrophage polarization
- Neutrophil extracellular traps
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Talk Citation
Mantovani, A. (2016, August 31). Humoral innate immunity and the acute phase response 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/PTJG2076.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Alberto Mantovani, Grant/Research Support (Principal Investigator): SIGMA-TAU, ROME
Humoral innate immunity and the acute phase response 2
A selection of talks on Immunology
Transcript
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0:03
Another class of components
of the humoral innate immunity
is represented by pentraxins.
And here, I will focus my attention
on pentraxin 3, PTX3.
PTX3 was originally cloned
in a gene fishing expedition
as in IL-1, or LPS,
or TNF inducible gene.
0:26
This slide is a schematic
representation
of the extraction of PTX3,
its genomic organization,
transcript, and protein.
And the molecule was cloned by us.
And we cloned a mouse
and the human cDNA in genomic
and characterized the promoter.
PTX3 is a soluble protein
consisting of a pentraxin domain
encoded by the third exon,
coupled with an unrelated
and terminal portion.
The model here suggests
the pentraxin domain
holds with a jelly-roll type
of the topology.
As other pentraxins,
PTX3 forms multimers,
but in contrast
to the classic short pentraxins,
which form a pentamer,
PTX3 is organized as an octamer.
And intra and inter-chain
disulfide bridges
play a key role in the multimeric
organization of PTX3.
1:21
The pentraxin domain of PTX3
is related to the
classic short pentraxins,
which include the C-reactive protein
and the serum amyloid P component.
C-reactive protein is a classic
acute phase protein in humans.
We were lucky
because we cloned the first member
of the long pentraxin family
in which a pentraxin domain
is coupled with unrelated
and terminal portions.
This slide emphasizes, in particular,
that we recently cloned
another member of the family
in silico, in physical,
that we called PTX4.
This slide also shows
an evolution of the analysis
of the pentraxin superfamily,
indicating that pentraxins
are ancient in evolution.
On the right side, one can see
the toll fish and drosophila.
And that the mother
of all pentraxins
was most likely a long pentraxin.