• Introduction to the World of Hormones
• 45 min
  1. Introduction to hormones

  • Prof. Helen Henry
• The Reproductive Hormones
• 44 min
  2. Endocrinology of parturition

  • Dr. Errol Norwitz
• 54 min
  3. Menopausal hormone therapy

  • Prof. Hugh Taylor
• 53 min
  4. Understanding hormones: mechanisms of androgen receptor function in reproduction and cancer

  • Prof. Elizabeth Wilson
• Hormones in Calcium and Phosphorus Homeostasis
• 36 min
  5. Vitamin D endocrine system: basics

  • Prof. Anthony Norman
• 47 min
  6. Vitamin D endocrine system: mechanisms to produce biological responses

  • Prof. Anthony Norman
• 37 min
  7. Parathyroid hormone and parathyroid hormone-related protein

  • Prof. Robert Nissenson
• 51 min
  8. Hormonal influence on bone remodeling and its implications for the pathophysiology of osteoporosis

  • Prof. Stavros Manolagas
• Hormones and the Vasculature
• 52 min
  9. Vascular cell signaling by membrane estrogen receptors

  • Prof. Jeffrey Bender
• Hormones and Energy Metabolism
• 41 min
  10. Pathogenesis of the metabolic syndrome

  • Prof. Richard Bergman
• Hormones and Growth
• 31 min
  11. The growth hormone/insulin-like growth factor-1 axis in health and disease

  • Prof. Derek LeRoith
• Frontiers in Hormone Research
• 47 min
  12. Prevention of type 1 diabetes

  • Prof. Chantal Mathieu
• 27 min
  13. Actions of steroid hormones in the brain

  • Prof. Bruce McEwen
• 40 min
  14. Vitamin D and prostate cancer

  • Prof. David Feldman
• Archived Lectures *These may not cover the latest advances in the field
• 46 min
  15. G-protein coupled receptors: hormone membrane receptors

  • Prof. Stuart Sealfon
• 40 min
  16. Nuclear receptors: transcriptional functions

  • Prof. Nancy Weigel
  • Dr. Neil McKenna
• 60 min
  17. Steroid hormones and their receptors in breast cancer

  • Prof. JoEllen Welsh
• 44 min
  18. Nuclear receptor superfamily: structural insights into function

  • Prof. Dino Moras
• 53 min
  19. Receptor tyrosine kinases - function, families and evolution

  • Prof. Tony Hunter
• 58 min
  20. Can we prevent type I diabetes?

  • Prof. Chantal Mathieu
• 39 min
  21. Vitamin D endocrine system: VDR binding, nutrition and drugs development

  • Prof. Anthony Norman

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. VDR conformational ensemble
3. Receptor ligand interactions
4. A vitamin D receptor ensemble model
5. VDR-1,25(OH)2D3 (G-pocket) complex
6. A modeling surprise: two pockets found
7. Summary: 1,25(OH)2D3 VDR G- and A-pockets
8. Summary of rapid responses
9. Vitamin D nutrition for good health
10. Where do we obtain vitamin D?
11. How much vitamin D do we need?
12. What is the RDA for vitamin D?
13. How do we obtain our vitamin D RDA? (1)
14. How do we obtain our vitamin D RDA? (2)
15. How do we obtain our vitamin D RDA? (3)
16. Skin cancer is linked to UVB exposure
17. World-wide vitamin D nutrition status
18. What is a measure of vitamin D status?
19. 25(OH)D levels in older women
20. Objective is to increase 25(OH)D in the population
21. Benefits from increasing 25(OH)D levels
22. Vitamin D status and intestinal calcium absorption
23. Nutritional summary
24. New research frontiers
25. Drug development: analogs of 1alpha,25(OH)2D3
26. Drug forms of 1,25(OH)2-vitamin D3 (hormone D)
27. Loss of VDR results in apolecia
28. Analogs of hormone D are effective for psoriasis
29. 1alpha,25(OH)2D3 and the innate immune system
30. Osteoporotic bone
31. Vitamin D in human disease states
32. Summary
33. 1alpha,25(OH)2D3 plus VDR - responses
34. Overall summary
35. Vitamin D3 vs. 1alpha,25(OH)2-vitamin D3
36. Thank you

Topics Covered

• VDR conformational ensemble
• A vitamin D receptor ensemble model
• X-ray crystal structure of the nuclear vitamin D receptor
• VDR G- and A-pocket
• Vitamin D nutrition for good health
• Sources of vitamin D
• How much vitamin D do we need?
• World-wide vitamin D nutrition status
• Vitamin D status and intestinal calcium absorption
• New research frontiers
• Drug development
• Alopecia
• Analogs of hormone D are effective for psoriasis
• hormone-D activates the innate immune system -Vitamin D in human disease states

Links

Series:

• The World of Hormones

Categories:

• Biochemistry
• Metabolism & Nutrition
• Physiology & Anatomy

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on December 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Anthony Norman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.